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However, flavonoids such as Luteolin might be of great value in the prevention of toxicity associated with accidental or inevitable ingestion of NaF. In the study, 40 male Wistar albino rats were randomly divided into four groups with 10 rats in a group. Group A was the control group and received normal saline, Group B was exposed to NaF at 300 ppm (300 mg\/L) in drinking water daily for a week, Groups C and D were exposed to 300 ppm (300 mg\/L) of NaF and coadministered with Luteolin orally daily at a dosage of 100 mg\/kg and 200 mg\/kg for the same time point. Our results indicated that NaF caused significant increases in systolic blood pressure, diastolic blood pressure, mean arterial pressure, malondialdehyde, protein carbonyl, myeloperoxidase, advanced oxidative protein products, together with significant reductions in glutathione peroxidase, superoxide dismutase, catalase, glutathione reductase, reduced glutathione, and nitric oxide (NO) bioavailability. The electrocardiogram results showed that NaF alone caused significant prolongation of QT and QTc intervals. Immunohistochemistry revealed that NaF caused increase expressions of Kidney injury marker 1 (Kim\u20101), nuclear factor kappa bet (NF\u2010\u03baB), nuclear factor erythroid 2\u2010related factors 2 (Nrf2), and cardiac troponin I (CTnI). Together, Luteolin coadministration with NaF improved NO bioavailability, reduced high blood pressure, markers of oxidative stress, reversed prolongation of QT and QTc intervals, and lowered the expressions of Kim\u20101, NF\u2010\u03baB, and CTnI. \u00a9 2018 BioFactors, 44(6):518\u2013531, 2018<\/jats:p>","DOI":"10.1002\/biof.1449","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T07:15:50Z","timestamp":1543216550000},"page":"518-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Luteolin\u2010mediated Kim\u20101\/NF\u2010kB\/Nrf2 signaling pathways protects sodium fluoride\u2010induced hypertension and cardiovascular complications"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8996-8610","authenticated-orcid":false,"given":"Ademola Adetokunbo","family":"Oyagbemi","sequence":"first","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temidayo Olutayo","family":"Omobowale","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufunke Eunice","family":"Ola\u2010Davies","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebunoluwa Racheal","family":"Asenuga","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine University of Benin  Benin City Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temitayo Olabisi","family":"Ajibade","sequence":"additional","affiliation":[{"name":"Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olumuyiwa Abiola","family":"Adejumobi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah Moyinoluwa","family":"Afolabi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blessing Seun","family":"Ogunpolu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufunke Olubunmi","family":"Falayi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adebowale Bernard","family":"Saba","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeolu Alex","family":"Adedapo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Ibadan  Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoh Audu","family":"Yakubu","sequence":"additional","affiliation":[{"name":"Department of Environmental and Interdisciplinary Sciences College of Science, Engineering and Technology, NSB303, Sr. Scientist &amp; Head, Vascular Biology Unit, Center for Cardiovascular Diseases, COPHS, Texas Southern University  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"91","article-title":"Effect of sodium fluoride on the morphological picture of the rat liver exposed to NaF in drinking water","volume":"51","author":"Dabrowska E.","year":"2006","journal-title":"Adv. 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