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This article reports the healing gastric ulcer activity of the hydroethanolic extract of\n                    <jats:italic>B. dracunculifolia<\/jats:italic>\n                    (HEBD) in an acetic acid\u2010induced ulcer model. In addition to the extract, the isolated compounds ferulic acid,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010coumaric acid, caffeic acid, baccharin, and aromadendrin\u20104\u2019\u2010O\u2010methyl ether were also assayed. HEBD at a dose of 300\u2009mg\/kg reduced the ulcerated area by 49.4% after treatment for 7 days, twice a day. Histological analyses revealed that the margins and base of the ulcer obtained significant regeneration, and periodic acid Schiff base staining showed a 78.2% increase in the mucin levels. The action on the enzymatic antioxidant system demonstrated an increased activity of superoxide dismutase and glutathione\u2010\n                    <jats:italic>S<\/jats:italic>\n                    \u2010transferase, in addition to raising glutathione reduced levels and myeloperoxidase activity. HEBD did not show cytotoxicity in the 3\u2010(4,5\u2010dimethylthiazol\u20102\u2010yl)\u20102,5\u2010diphenylterazole bromine test.\n                    <jats:italic>In vitro<\/jats:italic>\n                    , HEBD inhibited the H\n                    <jats:sup>+<\/jats:sup>\n                    \/K\n                    <jats:sup>+<\/jats:sup>\n                    \u2010ATPase enzyme and showed antioxidant activity in the 2,2 diphenyl\u20101\u2010picryllydrazyl test. Regarding the isolated compounds, oral administration of\n                    <jats:italic>p<\/jats:italic>\n                    \u2010coumaric acid (15\u2009mg\/kg) reduced the ulcerated area by 66.2%. The results suggest that HEBD recovers the gastric ulcerated tissue, raising mucus and antioxidant enzyme levels, and reducing the H\n                    <jats:sup>+<\/jats:sup>\n                    \/K\n                    <jats:sup>+<\/jats:sup>\n                    \u2010ATPase activity. In addition, the findings confirm that\n                    <jats:italic>p<\/jats:italic>\n                    \u2010coumaric acid is a pivotal bioactive compound on the gastric healing effects elicited by HEBD. \u00a9 2019 BioFactors, 45(3):479\u2013489, 2019\n                  <\/jats:p>","DOI":"10.1002\/biof.1503","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:28:11Z","timestamp":1555028891000},"page":"479-489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Hydroalcoholic extract from\n                    <i>Baccharis dracunculifolia<\/i>\n                    recovers the gastric ulcerated tissue, and\n                    <i>p<\/i>\n                    \u2010coumaric acid is a pivotal bioactive compound to this action"],"prefix":"10.1002","volume":"45","author":[{"given":"Philipe","family":"Costa","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico\u2010Farmac\u00eauticas, Universidade do Vale do Itaja\u00ed  Itaja\u00ed South Carolina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaise","family":"Boeing","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico\u2010Farmac\u00eauticas, Universidade do Vale do Itaja\u00ed  Itaja\u00ed South Carolina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lincon Bordignon","family":"Somensi","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico\u2010Farmac\u00eauticas, Universidade do Vale do Itaja\u00ed  Itaja\u00ed South Carolina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benhur Judah","family":"Cury","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico\u2010Farmac\u00eauticas, Universidade do Vale do Itaja\u00ed  Itaja\u00ed South Carolina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Lopes","family":"Esp\u00edndola","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico\u2010Farmac\u00eauticas, Universidade do Vale do Itaja\u00ed  Itaja\u00ed South Carolina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tauani Caroline Santos","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas N\u00facleo de Investiga\u00e7\u00f5es Qu\u00edmico\u2010Farmac\u00eauticas, Universidade do Vale do Itaja\u00ed  Itaja\u00ed South Carolina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia Oliveira","family":"de Almeida","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Arruda","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jairo Kenupp","family":"Bastos","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo 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