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Wistar rats (<jats:italic>n<\/jats:italic>\u2009=\u20098 per group) were given either a control (1,000\u2009IU D3\/kg diet) or a vitamin D deficient (VDD) (0 IU D3\/kg diet) diet from pre\u2010pregnancy to delivery. On day 20 of gestation, pregnant female rats were delivered by C\u2010section to collect placenta and blood. VDD group demonstrated high serum parathyroid hormone, low serum phosphate, low plasma folate, higher plasma homocysteine, and higher plasma malondialdehyde levels (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 for all) as compared to control. Lower protein levels of placental cystathionine\u2010\u03b2\u2010synthase enzyme (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) were observed in the VDD group as compared to control. VDD group demonstrated higher placental mRNA levels of the enzymes phospholipase A<jats:sub>2<\/jats:sub> and cyclooxygenase\u20102 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 for both) as compared to control. Protein levels of the enzymes phospholipase A<jats:sub>2<\/jats:sub> and cyclooxygenase\u20102 were lower (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 for both) in the VDD group as compared to the control group. The ratio of thromboxane B<jats:sub>2<\/jats:sub> and 6\u2010keto prostaglandin F<jats:sub>1\u03b1<\/jats:sub> in serum was higher (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in the VDD group as compared to control; although the serum levels of 6\u2010keto prostaglandin F<jats:sub>1\u03b1<\/jats:sub> and thromboxane B<jats:sub>2<\/jats:sub> were similar in both the groups. Our findings suggest that increased oxidative stress due to maternal vitamin D deficiency results in the imbalance between the vasoconstrictor (thromboxane B<jats:sub>2<\/jats:sub>) and vasodilator (6\u2010keto prostaglandin F<jats:sub>1\u03b1<\/jats:sub>) eicosanoids, which may lead to endothelial dysfunction and poor pregnancy outcome. \u00a9 2019 BioFactors, 45 (4):548\u2013555, 2019<\/jats:p>","DOI":"10.1002\/biof.1510","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T14:48:22Z","timestamp":1555339702000},"page":"548-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Maternal vitamin D deficiency increases the thromboxane\/prostacyclin ratio through alterations in the one\u2010carbon cycle in Wistar rats"],"prefix":"10.1002","volume":"45","author":[{"given":"Anindita A.","family":"Nandi","sequence":"first","affiliation":[{"name":"Department of Nutritional Medicine Mother and Child Health, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth  Pune Satara Road, Pune, 411043 Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha S.","family":"Wadhwani","sequence":"additional","affiliation":[{"name":"Department of Nutritional Medicine Mother and Child Health, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth  Pune Satara Road, Pune, 411043 Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0551-7183","authenticated-orcid":false,"given":"Sadhana R.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Nutritional Medicine Mother and Child Health, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth  Pune Satara Road, Pune, 411043 Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13968"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-017-1067-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.11.003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2018.02.013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2018.07.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-015-1267-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-00850"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.03.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.08.015"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.06.978"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1201\/b19151-11"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9121364"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-015-4098-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2014.05.006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8040216"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2018.03.005"},{"key":"e_1_2_8_18_1","first-page":"3","article-title":"Prostacyclin among prostanoids","volume":"60","author":"Gryglewski R. 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