{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:39:54Z","timestamp":1788381594728,"version":"build-2803163510"},"reference-count":209,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Traumatic brain injury (TBI) is the most prevalent health problem affecting all age groups, and leads to many secondary problems in other organs especially kidneys, gastrointestinal tract, and heart function. In this review, the search terms were TBI, fluid percussion injury, cold injury, weight drop impact acceleration injury, lateral fluid percussion, cortical impact injury, and blast injury. Studies with <jats:italic>Actaea racemosa<\/jats:italic>, <jats:italic>Artemisia annua<\/jats:italic>, <jats:italic>Aframomum melegueta<\/jats:italic>, <jats:italic>Carthamus tinctorius<\/jats:italic>, <jats:italic>Cinnamomum zeylanicum<\/jats:italic>, <jats:italic>Crocus sativus<\/jats:italic>, <jats:italic>Cnidium monnieri<\/jats:italic>, <jats:italic>Curcuma longa<\/jats:italic>, <jats:italic>Gastrodia elata<\/jats:italic>, <jats:italic>Malva sylvestris<\/jats:italic>, Da Chuanxiong Formula, <jats:italic>Erigeron breviscapus<\/jats:italic>, <jats:italic>Panax ginseng<\/jats:italic>, <jats:italic>Salvia tomentosa<\/jats:italic>, <jats:italic>Satureja khuzistanica<\/jats:italic>, <jats:italic>Nigella sativa<\/jats:italic>, <jats:italic>Drynaria fortune<\/jats:italic>, <jats:italic>Dracaena cochinchinensis<\/jats:italic>, <jats:italic>Polygonum cuspidatum<\/jats:italic>, <jats:italic>Rosmarinus officinalis<\/jats:italic>, <jats:italic>Rheum tanguticum<\/jats:italic>, <jats:italic>Centella asiatica<\/jats:italic>, and <jats:italic>Curcuma zedoaria<\/jats:italic> show a significant decrease in neuronal injury by different mechanisms such as increasing superoxide dismutase and catalase activities, suppressing nuclear factor kappa B (NF\u2010\u03baB), interleukin 1 (IL\u20101), glial fibrillary acidic protein, and IL\u20106 expression. The aim of this study was to evaluate the neuroprotective effects of medicinal plants in central nervous system pathologies by reviewing the available literature.<\/jats:p>","DOI":"10.1002\/biof.1516","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T18:54:27Z","timestamp":1560797667000},"page":"517-535","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited"],"prefix":"10.1002","volume":"45","author":[{"given":"Zakieh","family":"Keshavarzi","sequence":"first","affiliation":[{"name":"Natural Products and Medicinal Plants Research Center North Khorasan University of Medical Sciences  Bojnurd Iran"},{"name":"Department of Physiology School of Medicine, North Khorasan University of Medical Sciences  Bojnurd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzaneh","family":"Shakeri","sequence":"additional","affiliation":[{"name":"Natural Products and Medicinal Plants Research Center North Khorasan University of Medical Sciences  Bojnurd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George E.","family":"Barreto","sequence":"additional","affiliation":[{"name":"Departamento de Nutrici\u00f3n y Bioqu\u00edmica, Facultad de Ciencias Pontificia Universidad Javeriana  Bogot\u00e1 D.C. Colombia"},{"name":"Instituto de Ciencias Biom\u00e9dicas Universidad Aut\u00f3noma de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahram","family":"Bibak","sequence":"additional","affiliation":[{"name":"Natural Products and Medicinal Plants Research Center North Khorasan University of Medical Sciences  Bojnurd Iran"},{"name":"Department of Physiology School of Medicine, North Khorasan University of Medical Sciences  Bojnurd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thozhukat","family":"Sathyapalan","sequence":"additional","affiliation":[{"name":"Department of Academic Diabetes, Endocrinology and Metabolism Hull York Medical School, University of Hull  Hull HU3 2JZ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center Pharmaceutical Technology Institute, Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Neurogenic Inflammation Research Center Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001199-200609000-00001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1358"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01164.x"},{"key":"e_1_2_8_5_1","first-page":"231","article-title":"The effects of female sex steroids on gastric secretory responses of rat following traumatic brain injury","volume":"14","author":"Keshavarzi Z","year":"2011","journal-title":"Iran J Basic Med Sci"},{"key":"e_1_2_8_6_1","first-page":"1102","article-title":"The effects of cyclooxygenase inhibitors on the brain inflammatory response following traumatic brain injury in rats","volume":"15","author":"Khaksari M","year":"2012","journal-title":"Iran J Basic Med Sci"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.149815"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3407"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0481-y"},{"key":"e_1_2_8_10_1","first-page":"5653","article-title":"Increased miR\u2010155 and heme oxygenase\u20101 expression is involved in the protective effects of formononetin in traumatic brain injury in rats","volume":"9","author":"Li Z","year":"2017","journal-title":"Am J Transl Res"},{"key":"e_1_2_8_11_1","first-page":"3","article-title":"Neuroprotective effects of Aframomum melegueta extract after experimental traumatic brain injury","author":"Kumar A","year":"2015","journal-title":"Nat Prod Chem Res"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00590"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5720"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871527317666180501110918"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.11.027"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.02.016"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.02.004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.198990"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.03.018"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-013-0187-3"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2005.20.2.291"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22811"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.07.009"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-10-92"},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","first-page":"6099","DOI":"10.12659\/MSM.905429","article-title":"Malva sylvestris attenuates cognitive deficits in a repetitive mild traumatic brain injury rat model by reducing neuronal degeneration and astrocytosis in the hippocampus","volume":"23","author":"Qin H","year":"2017","journal-title":"Med Sci Monit: Int Med J Exp Clin Res"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37098"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-1655-x"},{"key":"e_1_2_8_28_1","first-page":"974","article-title":"Protective effect of rheum tanguticum polysaccharides (RTP) on traumatic brain injury in rats","volume":"28","author":"Wang Z","year":"2003","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15010895"},{"key":"e_1_2_8_30_1","unstructured":"MohamedAAG. Potential therapeutic effect of amlodipine and thymoquinone alone or in combination on traumatic brain injury in mice. CU Theses;2017.http:\/\/erepository.cu.edu.eg\/index.php\/cutheses\/article\/view\/7131\/6992"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.03.029"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5201"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/09637480701777944"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.78519"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2018.04.007"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25778"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000406"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-100019"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e32832c389e"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.03.026"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/112_2016_3"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666160527113501"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2013.07.019"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2000.9699556"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nen018"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2013.06.002"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1515\/tnsci-2018-0007"},{"key":"e_1_2_8_48_1","first-page":"2813","article-title":"Salvia miltiorrhiza: Chemical and pharmacological review of a medicinal plant","volume":"4","author":"Wang B\u2010Q","year":"2010","journal-title":"J Med Plant Res"},{"key":"e_1_2_8_49_1","first-page":"6","article-title":"Evaluation of extraction methods for isolation and detection of Formononetin in black cohosh (Actaea racemosa L.)","volume":"1","author":"Al\u2010Amier H","year":"2012","journal-title":"J Medicinally Active Plants"},{"key":"e_1_2_8_50_1","first-page":"65","article-title":"Comparative anti\u2010inflammatory activity of Cimicifuga racemosa and Mimosa pudica","volume":"9","author":"Rathore R","year":"2002","journal-title":"Asian J Anim Vet Adv"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2014.980254"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(02)00348-1"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2013.03.017"},{"key":"e_1_2_8_54_1","volume-title":"Medicinal plants of East Africa","author":"Kokwaro J","year":"1976"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1300\/J044v13n01_02"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1076\/phbi.34.1.64.13172"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209509065384"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/159343"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.10.013"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.4236\/ajps.2016.71013"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.3923\/ijp.2007.311.318"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.08.025"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf5026086"},{"key":"e_1_2_8_64_1","first-page":"35","article-title":"Further evaluation of the anti\u2013inflammatory activity of Aframomum melegueta seed extract and its possible mechanism of action","volume":"4","author":"Umukoro S","year":"2005","journal-title":"Niger J Health Clin Sci"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2650080706"},{"key":"e_1_2_8_66_1","first-page":"1","article-title":"Experimental animal studies on analgesic and anti\u2010nociceptive activity of Allium sativum (garlic) powder","volume":"2","author":"Jayanthi M","year":"2012","journal-title":"Indian J Res Rep Med Sci"},{"key":"e_1_2_8_67_1","first-page":"154","article-title":"Anticonvulsant potentials of Sesamum indicum and Allium sativum oil alone and in combination in animal models","volume":"3","author":"Advani U","year":"2011","journal-title":"Int J Pharm Pharm Sci"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.2174\/18715206113136660370"},{"key":"e_1_2_8_69_1","first-page":"589","article-title":"Antioxidant properties of raw garlic (Allium sativum) extract","volume":"19","author":"Rahman M","year":"2012","journal-title":"Int Food Res J"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2014.01.015"},{"key":"e_1_2_8_71_1","volume-title":"Seminars in cancer biology","author":"Efferth T","year":"2017"},{"key":"e_1_2_8_72_1","volume-title":"The encyclopedia of medicinal plants","author":"Chevallier A","year":"1996"},{"key":"e_1_2_8_73_1","unstructured":"StuartG(1984)Chinese Materia Medica. Taipei. Southern Materials Centre. A translation of an ancient Chinese herbal."},{"key":"e_1_2_8_74_1","first-page":"S219","volume-title":"Handbook of Chinese herbs and formulas","author":"Him\u2010Che Y","year":"1985"},{"key":"e_1_2_8_75_1","first-page":"xii, 366","volume-title":"A field guide to medicinal plants: Eastern and Central North America","author":"Foster S","year":"1990"},{"key":"e_1_2_8_76_1","unstructured":"SimonJE CharlesD CebertE GrantL JanickJ WhipkeyA.Artemisia annua L.: A promising aromatic and medicinal. p. 522\u2013526. In: J. Janick and J.E. Simon (eds.) Advances in new crops. Timber Press Portland OR."},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v15i3.17"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2015.19.1.21"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2004.05.003"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2015.11.001"},{"key":"e_1_2_8_81_1","first-page":"35","article-title":"Secondary metabolites of Artemisia annua and their biological activity","volume":"80","author":"Bhakuni R","year":"2001","journal-title":"Curr Sci"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.3923\/ajps.2010.299.306"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.001"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2009.02.019"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-008-9884-5"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.06.021"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep22135"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.06.007"},{"key":"e_1_2_8_89_1","first-page":"1368","article-title":"Carthamus tinctorius L. ameliorates brain injury followed by cerebral ischemia\u2010reperfusion in rats by antioxidative and anti\u2010inflammatory mechanisms","volume":"19","author":"Fu P\u2010K","year":"2016","journal-title":"Iranian J Basic Med Sci"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf050183e"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-275"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2018.01.009"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-765X.2002.01165.x"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-015-0296-3"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1643"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5822"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880200903019234"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116566"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130398"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-014-9552-2"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.156795"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.02.022"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.03.038"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2009-5-610"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(95)00044-N"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(199605)10:3<189::AID-PTR754>3.0.CO;2-C"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5622"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2597"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.18433\/J38G6J"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf300589c"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2012.10.008"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.12.014"},{"key":"e_1_2_8_113_1","first-page":"425369","article-title":"Phytochemical and pharmacological review of Da Chuanxiong Formula: A famous herb pair composed of chuanxiong rhizoma and gastrodiae rhizoma for headache","volume":"2013","author":"Wang L","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12107265"},{"key":"e_1_2_8_115_1","first-page":"376","article-title":"Chemical constituents from Erigeron bonariensis L. and their chemotaxonomic importance","volume":"6","author":"Zahoor A","year":"2012","journal-title":"Rec Nat Prod"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(03)00068-6"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X08006521"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.128.805"},{"key":"e_1_2_8_119_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/309261","article-title":"Neuropharmacological potential of Gastrodia elata Blume and its components","volume":"2015","author":"Jang J\u2010H","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.11.048"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2016.10.013"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2011.06.029"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X0500320X"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X09006916"},{"key":"e_1_2_8_125_1","first-page":"1","article-title":"A review on biological activities of common mallow (Malva sylvestris L.)","volume":"4","author":"Paul D","year":"2016","journal-title":"Innovare J Life Sci"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200225050-00003"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0147291777000209"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2016.1118345"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.31.139"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.06.020"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.5142\/jgr.2011.35.4.429"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2015.07.006"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.5142\/jgr.2013.37.167"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.01.051"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.08.022"},{"key":"e_1_2_8_136_1","first-page":"1671","article-title":"Effects of ginseng total saponin on traumatic brain edema of rats","volume":"32","author":"Xia L","year":"2012","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"e_1_2_8_137_1","first-page":"34","article-title":"Study survey on rhubarb in recent years","volume":"8","author":"Li M","year":"2006","journal-title":"World Sci Technol\/Mod Tradit Chin Med Materia Med"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10661-012-2935-z"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-012-0075-1"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.3906\/tar-1211-72"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(01)00335-5"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1100266"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(95)00210-4"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.3987\/R-1985-04-0953"},{"key":"e_1_2_8_145_1","first-page":"377","article-title":"Structural studies on a saponin isolated from the seeds of Nigella sativa","volume":"27","author":"Ansari A","year":"1989","journal-title":"Phyto Chem"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2007.00509.x"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1309"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.06.023"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1078\/0944-7113-00376"},{"key":"e_1_2_8_150_1","first-page":"1547","article-title":"Anxiolytic and hyperlocomotive effects of aqueous extract of Nigella sativa L. seeds in rats","volume":"27","author":"Bano F","year":"2014","journal-title":"Pak J Pharm Sci"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00340-X"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.92740"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules190710650"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.03.063"},{"key":"e_1_2_8_155_1","first-page":"84","article-title":"The chemical constituents and pharmaceutical activities of Dragon's blood, a famous traditional medicinal herb","volume":"17","author":"Zheng Q","year":"2005","journal-title":"Nat Prod Res Dev"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.10.012"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2006.01.006"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756360801936399"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12314"},{"key":"e_1_2_8_160_1","first-page":"1240","article-title":"Anti\u2010neuron apoptosis of Resina Draconis water extracts on rats with traumatic brain injury","volume":"27","author":"Zhang J","year":"2016","journal-title":"Biomed Res"},{"key":"e_1_2_8_161_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00823.x"},{"key":"e_1_2_8_162_1","first-page":"2545","article-title":"Pharmacological of Polygoni cuspidati rhizoma","volume":"38","author":"Fan H","year":"2013","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"e_1_2_8_163_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152012802650048"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-009-0387-8"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2014-0465"},{"key":"e_1_2_8_166_1","first-page":"15213","article-title":"Emodin attenuates brain edema after traumatic brain injury in rats","volume":"10","author":"Zeng J\u2010P","year":"2017","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-43.3.195"},{"issue":"4","key":"e_1_2_8_168_1","first-page":"741","article-title":"Anti\u2010inflammatory andantinociceptive effects ofRosmarinus officinalis L. essential oil inexperimental animal models","volume":"11","author":"Takaki I","year":"2008","journal-title":"J MedFood"},{"key":"e_1_2_8_169_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb1961.47.521"},{"key":"e_1_2_8_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(91)90161-6"},{"key":"e_1_2_8_171_1","first-page":"875","article-title":"The neuroprotective effect of rosemary (Rosmarinus officinalis L.) hydro\u2010alcoholic extract on cerebral ischemic tolerance in experimental stroke","volume":"15","author":"Seyedemadi P","year":"2016","journal-title":"Iran J Pharm Res"},{"key":"e_1_2_8_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.04.048"},{"key":"e_1_2_8_173_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020600782454"},{"key":"e_1_2_8_174_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040738"},{"key":"e_1_2_8_175_1","first-page":"569","article-title":"Evaluation of topical formulations of aqueous extract of Centella asiatica on open wounds in rats","volume":"36","author":"Parameshwaraiah S","year":"1998","journal-title":"Indian J Exp Biol"},{"key":"e_1_2_8_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(01)00394-4"},{"key":"e_1_2_8_177_1","first-page":"870","article-title":"Effect of total triterpenes from Centella asiatica on the depression behavior and concentration of amino acid in forced swimming mice","volume":"26","author":"Chen Y","year":"2003","journal-title":"Zhong Yao Cai"},{"key":"e_1_2_8_178_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1993.tb03532.x"},{"key":"e_1_2_8_179_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms10093713"},{"key":"e_1_2_8_180_1","first-page":"210","article-title":"Effect of Centella asiatica on pathophysiology of mild chronic cerebral hypoperfusion in rats","volume":"8","author":"Thong\u2010asa W","year":"2018","journal-title":"Avicenna J Phytomed"},{"key":"e_1_2_8_181_1","doi-asserted-by":"publisher","DOI":"10.14499\/indonesianjcanchemoprev6iss3pp105-110"},{"key":"e_1_2_8_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.01.005"},{"key":"e_1_2_8_183_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-016-0301-4"},{"key":"e_1_2_8_184_1","first-page":"155","article-title":"The effect of hydro\u2010ethanolic extract of Curcuma longa rhizome and curcumin on total and differential WBC and serum oxidant, antioxidant biomarkers in rat model of asthma","volume":"20","author":"Shakeri F","year":"2017","journal-title":"Iranian J Basic Med Sci"},{"key":"e_1_2_8_185_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25778"},{"key":"e_1_2_8_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2016.10.001"},{"key":"e_1_2_8_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.09.004"},{"key":"e_1_2_8_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.04.042"},{"key":"e_1_2_8_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.08.027"},{"key":"e_1_2_8_190_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968310397706"},{"key":"e_1_2_8_191_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06630.x"},{"key":"e_1_2_8_192_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-11-59"},{"key":"e_1_2_8_193_1","first-page":"375","article-title":"Evaluation of anti\u2010ulcer effect of root of Curcuma zedoaria in rats","volume":"2","author":"Gupta RP","year":"2003","journal-title":"Indian J Tradit Know"},{"key":"e_1_2_8_194_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-346"},{"key":"e_1_2_8_195_1","first-page":"349","article-title":"Neuroprotective and antioxidant constituents from Curcuma zedoaria rhizomes","volume":"9","author":"Hamdi OAA","year":"2015","journal-title":"Rec Natl Prod"},{"key":"e_1_2_8_196_1","first-page":"88","article-title":"Effect of aqueous extract of Curcuma zedoaria and Gloriosa superba against DMH\u2010induced colon carcinogenesis in Wistar rats","volume":"8","author":"Shaikh A","year":"2015","journal-title":"Int J PharmTech Res"},{"key":"e_1_2_8_197_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S139362"},{"key":"e_1_2_8_198_1","first-page":"1089","article-title":"Salvia miltiorrhiza and ischemic diseases","volume":"21","author":"Ji X\u2010Y","year":"2000","journal-title":"Acta Pharmacol Sin"},{"key":"e_1_2_8_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2010.11.015"},{"key":"e_1_2_8_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(99)00209-3"},{"key":"e_1_2_8_201_1","first-page":"102","article-title":"An anti\u2010inflammatory and anti\u2010nociceptive effects of hydroalcoholic extract of Satureja khuzistanica Jamzad extract. Journal of pharmacy & pharmaceutical sciences: A publication of the Canadian Society for Pharmaceutical Sciences","volume":"8","author":"Amanlou M","year":"2005","journal-title":"Societe canadienne des sciences pharmaceutiques"},{"key":"e_1_2_8_202_1","doi-asserted-by":"publisher","DOI":"10.1080\/15376520600620125"},{"key":"e_1_2_8_203_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31866"},{"key":"e_1_2_8_204_1","volume-title":"Botanical medicine for Women's health E\u2010book","author":"Romm A","year":"2017"},{"key":"e_1_2_8_205_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.345"},{"key":"e_1_2_8_206_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1842"},{"key":"e_1_2_8_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.04.031"},{"key":"e_1_2_8_208_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9385-x"},{"key":"e_1_2_8_209_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-009-0164-x"},{"key":"e_1_2_8_210_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/680756"}],"container-title":["BioFactors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbiof.1516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.1516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T15:54:04Z","timestamp":1694274844000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/biof.1516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,17]]},"references-count":209,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1002\/biof.1516"],"URL":"https:\/\/doi.org\/10.1002\/biof.1516","archive":["Portico"],"relation":{},"ISSN":["0951-6433","1872-8081"],"issn-type":[{"value":"0951-6433","type":"print"},{"value":"1872-8081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,17]]},"assertion":[{"value":"2019-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}