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Curcumin has useful biological features that include antioxidant, anti\u2010inflammatory, and anticancer properties. This review covers aspects of curcumin in relation to prevention of drug\u2010induced nephrotoxicity: dosage and schedule, effect on kidney biomarkers and histological changes, and mechanisms of curcumin's protective effects. Despite success in some animal models, human studies and clinical administration of curcumin for nephroprotection remains limited due to difficulty in achieving therapeutic levels following oral administration and in determining the optimal dosing schedule. Lack of sufficient evidence from animal studies, coupled with low systemic bioavailability, continues to limit the utilization of curcumin in addressing and controlling drug\u2010induced nephrotoxicity. 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