{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:42:47Z","timestamp":1771486967152,"version":"3.50.1"},"reference-count":67,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T00:00:00Z","timestamp":1308009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Since the time a precise role of coenzyme Q<jats:sub>10<\/jats:sub> (CoQ<jats:sub>10<\/jats:sub>) in myocardial bioenergetics was established, the involvement of CoQ in the pathophysiology of heart failure was hypothesized. This provided the rationale for numerous clinical trials of CoQ<jats:sub>10<\/jats:sub> as adjunctive treatment for heart failure. A mild hypotensive effect of CoQ was reported in the early years of clinical use of this compound. We review early human and animal studies on the vascular effects of CoQ. We then focus on endothelial dysfunction in type 2 diabetes and the possible impact on this condition of antioxidants and nutritional supplements, and in particular the therapeutic effects of CoQ. The effect of CoQ<jats:sub>10<\/jats:sub> on endothelial dysfunction in ischemic heart disease is also reviewed together with recent data highlighting that treatment with CoQ<jats:sub>10<\/jats:sub> increases extracellular SOD activity.<\/jats:p>","DOI":"10.1002\/biof.154","type":"journal-article","created":{"date-parts":[[2011,6,15]],"date-time":"2011-06-15T10:00:03Z","timestamp":1308132003000},"page":"366-373","source":"Crossref","is-referenced-by-count":41,"title":["Coenzyme Q<sub>10<\/sub>, endothelial function, and cardiovascular disease"],"prefix":"10.1002","volume":"37","author":[{"given":"Gian Paolo","family":"Littarru","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Tiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romualdo","family":"Belardinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald F.","family":"Watts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6,14]]},"reference":[{"key":"e_1_2_9_2_2","first-page":"291","article-title":"Deficiency of coenzyme Q10 in human heart disease. I","volume":"42","author":"Littarru G. P.","year":"1972","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"e_1_2_9_3_2","first-page":"413","article-title":"Deficiency of coenzyme Q10 in human heart disease. II","volume":"42","author":"Littarru G. P.","year":"1972","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.3.901"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520180210"},{"key":"e_1_2_9_6_2","first-page":"721","article-title":"Bioenergetics in clinical medicine. VIII. Administration of coenzyme Q10 to patients with essential hypertension","volume":"14","author":"Yamagami T.","year":"1976","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"e_1_2_9_7_2","first-page":"129","article-title":"Bioenergetics in clinical medicine. XVI. Reduction of hypertension in patients by therapy with coenzyme Q10","volume":"31","author":"Folkers K.","year":"1981","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"e_1_2_9_8_2","first-page":"417","volume-title":"Biomedical and Clinical Aspects of Coenzyme Q","author":"Montaldo P. L.","year":"1991"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0098-2997(94)90036-1"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0098-2997(94)90037-X"},{"key":"e_1_2_9_11_2","first-page":"95","article-title":"Bioenergetics in clinical medicine: studies on coenzyme Q10 and essential hypertension","volume":"11","author":"Yamagami T.","year":"1975","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1000778"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-200111000-00015"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601464"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(94)01551-V"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701970"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FP0072365"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00994-X"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-5-4"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1537-1891(02)00250-1"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000110785.96039.f6"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hch089"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200565010-00003"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2010.05455.x"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00430-2"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.1.208"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nuclcard.2006.01.022"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807233390404"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.3132\/dvdr.2007.026"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-001-0760-y"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(02)00417-3"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0118"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1736"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.04.022"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(98)00170-1"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:REMD.0000032407.88070.0a"},{"key":"e_1_2_9_37_2","first-page":"71","article-title":"Endothelial dysfunction and antioxidants","volume":"72","author":"Duvall W. L.","year":"2005","journal-title":"Mt. Sinai J. Med."},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118394"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00551-2"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2005.01767.x"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.093112"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2004.01201.x"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs1030339"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00768.2005"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.1999.00049.x"},{"key":"e_1_2_9_46_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1210\/jcem.85.1.6258","article-title":"Chronic Vitamin E administration Improves brachial reactivity and increases intracellular magnesium concentration in type II diabetic patients","volume":"85","author":"Paolisso G.","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051478"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x03vm489oa"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00403.2003"},{"key":"e_1_2_9_50_2","first-page":"428","article-title":"The cardiovascular protective effect of red wine","volume":"200","author":"Cordova A. C.","year":"2005","journal-title":"JACS"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.03.019"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2004.09.010"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051551"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.612325"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-0862-1"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.08.036"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x06vm664oa"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60104-X"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.46.11.1055"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2010.502529"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl158"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00617-8"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2220649"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.19.2264"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm267"},{"key":"e_1_2_9_66_2","first-page":"529","article-title":"In vitro effect of different ubiquinones on the scavenging of biologically generated O\u2212\n                  2","volume":"11","author":"Littarru G. P.","year":"1985","journal-title":"Drugs Exp. Clin. Res."},{"key":"e_1_2_9_67_2","doi-asserted-by":"publisher","DOI":"10.1163\/156856700X00778"},{"key":"e_1_2_9_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00328-0"}],"container-title":["BioFactors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbiof.154","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T11:20:07Z","timestamp":1694517607000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/biof.154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,14]]},"references-count":67,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1002\/biof.154"],"URL":"https:\/\/doi.org\/10.1002\/biof.154","archive":["Portico"],"relation":{},"ISSN":["0951-6433","1872-8081"],"issn-type":[{"value":"0951-6433","type":"print"},{"value":"1872-8081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,14]]}}}