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However, the response to supplementation, with respect to the increase in serum 25(OH)D level varies between individuals. In this study, we have assessed the factors associated with the response to VitD supplementation using a decision\u2010tree algorithm. Serum VitD levels, pre\u2010 and post\u2010VitD supplementation was used as the determinant of responsiveness. The model was validated by constructing a receiver operating characteristic curve. Serum VitD at baseline levels was at the apex of the tree in our model, followed by serum low\u2010density lipoprotein cholesterol and triglyceride, age, waist\u2010hip ratio, and high\u2010density lipoprotein cholesterol. Our model suggests that these determinants of responsiveness to VitD supplementation had sensitivity, specificity, and accuracy, 59.4, 75.8 and 69.3%, respectively. The decision tree model appears to be a relatively accurate, specific, and sensitive approach for identifying the factors associated with response to VitD supplementation.<\/jats:p>","DOI":"10.1002\/biof.1540","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T14:09:49Z","timestamp":1564409389000},"page":"795-802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Determinants of the magnitude of response to vitamin D supplementation in adolescent girls identified using a decision tree algorithm"],"prefix":"10.1002","volume":"45","author":[{"given":"Kayhan","family":"Gonoodi","sequence":"first","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Tayefi","sequence":"additional","affiliation":[{"name":"Norwegian Center for e\u2010health Research University hospital of North Norway  Troms\u00f8 Norway"},{"name":"Clinical Research Unit Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afsane","family":"Bahrami","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center Birjand University of Medical Sciences  Birjand Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Amirabadi Zadeh","sequence":"additional","affiliation":[{"name":"Medical Toxicology and Drug Abuse Research Center (MTDRC) Birjand University of Medical Sciences  Birjand Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon A.","family":"Ferns","sequence":"additional","affiliation":[{"name":"Brighton &amp; Sussex Medical School Division of Medical Education  Sussex UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzaneh","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeid","family":"Eslami","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Center Mashhad University of Medicine, Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of Medical Informatics, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1081-6754","authenticated-orcid":false,"given":"Majid","family":"Ghayour Mobarhan","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Metabolic Syndrome Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000484634"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26216"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26084"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.1.204"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.6.1657"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.6.1952"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","unstructured":"GallagherJC SaiA. 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