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This study focused on the potential therapeutic effect of wogonin on complete Freund's adjuvant (CFA) induced RA in rats and the underlying mechanisms. Arthritis was experimentally caused in rats by subcutaneously injecting 0.1 mL of CFA into the subplantar area of the left hind paw under moderate anesthesia on day zero. The regular oral doses of indomethacin\/wogonin began on day zero and proceeded after injection to day 35. Wogonin reduced arthritic score considerably, enhanced body weight, and reduced paw thickness. Wogonin also boosted red blood cell considerably along with hemoglobin and reduced white blood cell count and erythrocyte sedimentation rate. Wogonin substantially improved an altered level of oxidative stress markers, antioxidant proteins, and inflammatory cytokines in a dose\u2010dependent way. Wogonin inhibited p38 phosphorylation triggered by CFA and p65 nuclear translocation.<\/jats:p>","DOI":"10.1002\/biof.1585","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T06:21:02Z","timestamp":1573626062000},"page":"283-291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Wogonin ameliorate complete Freund's adjuvant induced rheumatoid arthritis via targeting NF\u2010\u03baB\/MAPK signaling pathway"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-7979","authenticated-orcid":false,"given":"Yuntai","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Rheumatology The First Affiliated Hospital of Henan University of Traditional Chinese Medicine  Zhengzhou Henan Province 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