{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:59:31Z","timestamp":1790589571794,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T00:00:00Z","timestamp":1578009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872791"],"award-info":[{"award-number":["31872791"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019MC046"],"award-info":[{"award-number":["ZR2019MC046"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Little is known about the influence of central nesfatin\u20101 on lipid metabolism under diabetic conditions. The main objective of this study was to characterize the mechanisms by which central nesfatin\u20101 regulates lipid metabolism in streptozotocin (STZ)\u2010induced type 2 diabetes mellitus (T2DM) and whether the sympathetic nervous system is involved. Male Kunming mice were fed high\u2010fat diets (HFDs) and were treated twice with low\u2010dose STZ (100\u2009mg\/kg, intraperitoneal [IP]) to generate the T2DM model. Pharmacological adrenergic blockage (phentolamine 10 mg\/kg, propranolol 0.017\u2009mmol) and surgical denervation of sympathetic nervous system of the hindlimb and inguinal fat were used to block nerve conduction to determine whether the effect of central nesfatin\u20101 required the hypothalamic\u2010sympathetic nervous system axis. Plasma free fatty acid (FFA) and insulin levels were measured. AMP\u2010activated protein kinase (AMPK) levels in skeletal muscle and hormone\u2010sensitive lipase and adipose triglycerides lipase (HSL\/ATGL) levels in white adipose tissue (WAT) were measured using western blot. mRNA expression of AMPK was measured. We found that there were significantly fewer NUCB2\/nesfatin\u20101 immunoreactive neurons in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) in T2DM mice. Central nesfatin\u20101 administration decreased levels of plasma FFA significantly and activated AMPK to enhance fatty\u2010acid oxidation in skeletal muscle in T2DM mice. In addition, HSL and ATGL were significantly activated during triglyceride mobilization in WAT triggered by central nesfatin\u20101 administration. Adrenergic blockade and morphological denervation of the sciatic and femoral nerves reduced these changes. Taken together, these data suggest that central nesfatin\u20101 regulates peripheral lipid metabolism in type 2 diabetes via the sympathetic nervous system.<\/jats:p>","DOI":"10.1002\/biof.1600","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T09:38:48Z","timestamp":1578044328000},"page":"454-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Central nesfatin\u20101 activates lipid mobilization in adipose tissue and fatty acid oxidation in muscle via the sympathetic nervous system"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9220-4905","authenticated-orcid":false,"given":"Yuan","family":"Liu","sequence":"first","affiliation":[{"name":"Special Medicine Department, Basic Medical College Qingdao University  Qingdao 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