{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T04:31:58Z","timestamp":1769920318330,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lipocalin\u20102 (LCN2) is a secreted glycoprotein involved in several chronic inflammatory processes. Metabolic syndrome (MetS) and adult growth hormone deficiency (GHD) are known as chronic inflammatory conditions. The primary objective of this observational cross\u2010sectional study was to compare LCN2 plasmatic levels in these clinical settings, whereas the secondary objective was to investigate any possible correlation between LCN2 and BMI and\/or indexes of insulin sensitivity\/resistance. Seventy\u2010four patients were divided as follows: Group A, MetS (18 patients, 13 females and 5 males, mean\u2009\u00b1\u2009<jats:italic>SEM<\/jats:italic> age 45.1\u2009\u00b1\u20094.11\u2009years, BMI 31.22\u2009\u00b1\u20091.73\u2009kg\/m<jats:sup>2<\/jats:sup>); Group B, total GHD (18 patients, 8 females and 10 males, age 52.44\u2009\u00b1\u20092.61\u2009years, BMI 30.49\u2009\u00b1\u20091.87\u2009kg\/m<jats:sup>2<\/jats:sup>); Group C, Partial GHD (pGHD; 19 patients, 13 females and 6 males, age 48.63\u2009\u00b1\u20092.19\u2009years, BMI 29.11 \u00b1\u20091.85\u2009kg\/m<jats:sup>2<\/jats:sup>); Group D, Controls (19 patients, 13 females and 6males, age 40.26\u2009\u00b1\u20092.87\u2009years, BMI 23.25\u2009\u00b1\u20090.95\u2009kg\/m<jats:sup>2<\/jats:sup>). They were evaluated for glucose and insulin, HOMA\u2010index, QUICKI\u2010index, Total\/low\u2010density lipoprotein\/high\u2010density lipoprotein cholesterol, triglycerides, uric acid, IGF\u20101, and LCN2. LCN2 plasmatic levels were significantly increased in MetS, while no significant differences with controls were found in total and pGHD. LCN2 levels did not correlate with BMI. A significant positive correlation between LCN2 and HOMA\u2010index was found in controls, while a trend\u2010like, yet not significant, a positive correlation was observed in pGHD. Our data show an increase in LCN2 plasmatic levels in MetS. Different inflammatory patterns characterize MetS and GHD. The correlation between HOMA index and LCN2 in normal subjects and possibly in pGHD ones suggests a modulatory action of LCN2 on insulin resistance.<\/jats:p>","DOI":"10.1002\/biof.1628","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T18:45:55Z","timestamp":1584729955000},"page":"629-636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Plasmatic lipocalin\u20102 levels in chronic low\u2010grade inflammation syndromes: Comparison between metabolic syndrome, total and partial adult growth hormone deficiency"],"prefix":"10.1002","volume":"46","author":[{"given":"Diego","family":"Curr\u00f2","sequence":"first","affiliation":[{"name":"Istituto di Farmacologia Universit\u00e0 Cattolica del Sacro Cuore  Roma Italy"},{"name":"Unit\u00e0 Operativa Complessa di Farmacologia, Direzione Sanitaria Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Vergani","sequence":"additional","affiliation":[{"name":"UOC Endocrinologia e Diabetologia Fondazione Policlinico Universitario A. Gemelli IRCCS  Roma Italy"},{"name":"Dipartimento di Medicina e Chirurgia Traslazionale Fondazione Policlinico Universitario A. Gemelli IRCCS  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3489-0238","authenticated-orcid":false,"given":"Carmine","family":"Bruno","sequence":"additional","affiliation":[{"name":"UOC Endocrinologia e Diabetologia Fondazione Policlinico Universitario A. Gemelli IRCCS  Roma Italy"},{"name":"Dipartimento di Medicina e Chirurgia Traslazionale Fondazione Policlinico Universitario A. Gemelli IRCCS  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Comi","sequence":"additional","affiliation":[{"name":"UOC Endocrinologia e Diabetologia Fondazione Policlinico Universitario A. Gemelli IRCCS  Roma Italy"},{"name":"Dipartimento di Medicina e Chirurgia Traslazionale Fondazione Policlinico Universitario A. Gemelli IRCCS  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"D'Abate","sequence":"additional","affiliation":[{"name":"UOC Endocrinologia e Diabetologia Fondazione Policlinico Universitario A. Gemelli IRCCS  Roma Italy"},{"name":"Dipartimento di Medicina e Chirurgia Traslazionale Fondazione Policlinico Universitario A. Gemelli IRCCS  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9417-6810","authenticated-orcid":false,"given":"Antonio","family":"Mancini","sequence":"additional","affiliation":[{"name":"UOC Endocrinologia e Diabetologia Fondazione Policlinico Universitario A. Gemelli IRCCS  Roma Italy"},{"name":"Dipartimento di Medicina e Chirurgia Traslazionale Fondazione Policlinico Universitario A. Gemelli IRCCS  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(00)00152-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071816-064559"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.38.22565"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.04.040"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2493"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2015.1123354"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.03.007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1179721"},{"key":"e_1_2_9_10_1","first-page":"174","article-title":"Obesity\u2010associated low\u2010grade inflammation in type 2 diabetes mellitus: Causes and consequences","volume":"4","author":"Greevenbroek MMJ","year":"2013","journal-title":"Neth J Med"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1411"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319246"},{"issue":"6","key":"e_1_2_9_13_1","first-page":"543","article-title":"Inflamaci\u00f3n sist\u00e9mica de grado bajo y su relaci\u00f3n con el desarrollo de enfermedades metab\u00f3licas: de la evidencia molecular a la aplicaci\u00f3n cl\u00ednica","volume":"83","author":"Le\u00f3n\u2010Pedroza JI","year":"2015","journal-title":"Cir Cir"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1533\/9780857095749.1.105"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1937"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7678183"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.03.001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.06.001"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-009-0486-8"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.61"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0007"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.07.845"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1541"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1735"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00147.2011"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.08.026"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.242"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0660"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00416"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92328-3"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb01860.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0291"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01832.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1468-1"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2014.11.002"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03292.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.4.5605"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2566"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1042"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030761"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.06.006"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0179"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1444"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.075614"},{"key":"e_1_2_9_47_1","first-page":"762","article-title":"Increased lipocalin\u20102 vs reduced oxytocin in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes","volume":"119","author":"Tofiq KO","year":"2018","journal-title":"Bratisl Lek Listy"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1062746"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.113989"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303950"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000837"},{"key":"e_1_2_9_52_1","first-page":"859","article-title":"Serum neutrophil gelatinase\u2010associated lipocalin (Ngal) correlates with clinical and endoscopic activity in ulcerative colitis but fails to predict activity in Crohn's disease","volume":"68","author":"Budzynska A","year":"2017","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.23"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360689"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.04.006"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0039"}],"container-title":["BioFactors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbiof.1628","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.1628","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/biof.1628","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.1628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:58:12Z","timestamp":1693961892000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/biof.1628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,20]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/biof.1628"],"URL":"https:\/\/doi.org\/10.1002\/biof.1628","archive":["Portico"],"relation":{},"ISSN":["0951-6433","1872-8081"],"issn-type":[{"value":"0951-6433","type":"print"},{"value":"1872-8081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,20]]},"assertion":[{"value":"2019-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}