{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:16:48Z","timestamp":1789535808505,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Kidney Research Center at Tabriz University of Medical Sciences, Tabriz, Iran","award":["58122"],"award-info":[{"award-number":["58122"]}]}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Podocytes play an essential role in the regulation of glomerular filtration and the appropriate function of the kidney. Podocytes injury is involved in the pathogenesis of nephrotic syndrome (NS), a common renal glomerulus dysfunction characterized by proteinuria. Some in vivo studies in Dicer\/Drosha knockout mice indicate the importance of Dicer, Drosha, and microRNAs (miRNAs) in the pathogenesis of NS. In the present study, the expression levels of Dicer and Drosha along with miR\u201030 family, miR\u2010186, miR\u2010193, and miR\u2010217 were evaluated in peripheral blood mononuclear cell samples of patients with NS (<jats:italic>N<\/jats:italic> =\u200960) using real\u2010time PCR. Dicer expression level in NS patients was significantly upregulated when compared to healthy controls (<jats:italic>p<\/jats:italic> =\u2009.008). No significant change was observed in the Drosha expression level in the NS group. Upregulated levels of the studied microRNAs were observed in NS group in comparison to controls, the miR\u201030c\u20105p (<jats:italic>p<\/jats:italic> =\u2009.005) and miR\u2010193\u20103p (<jats:italic>p<\/jats:italic> =\u2009.041) were statistically significant. In conclusion, dysregulation in expression level of Dicer and Drosha and consequently, alteration in miRNA levels are involved in the pathophysiology of NS.<\/jats:p>","DOI":"10.1002\/biof.1638","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T05:59:38Z","timestamp":1589608778000},"page":"645-652","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dicer and Drosha expression in patients with nephrotic syndrome"],"prefix":"10.1002","volume":"46","author":[{"given":"Seyyedeh Mina","family":"Hejazian","sequence":"first","affiliation":[{"name":"Kidney Research Center Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Department of Medical Biotechnology, Faculty of Advanced Medical Sciences Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Student Research Committee, Tabriz University of Medical Sciences  Tabriz 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