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Thus, luteolin can also decrease adverse photobiological effects in the skin by acting as a first line of defense. Furthermore, anti\u2010oxidative and anti\u2010inflammatory activities of luteolin were described on keratinocytes and fibroblasts as well as on several immune cells (e.g., macrophages, mast cell, neutrophils, dendritic cells and T cells). Luteolin can suppress proinflammatory mediators (e.g., IL\u20101\u03b2, IL\u20106, IL\u20108, IL\u201017, IL\u201022, TNF\u2010\u03b1 and COX\u20102) and regulate various signaling pathway (e.g., the NF\u2010\u03baB, JAK\u2013STAT as well as TLR signaling pathway). In this way, luteolin modulates many inflammatory processes of the skin. The present review summarizes the recent in vitro and in vivo research on luteolin in the field of skin aging and skin cancer, wound healing as well as inflammatory skin diseases, including psoriasis, contact dermatitis and atopic dermatitis. In conclusion, luteolin might be a promising molecule for the development of topic formulations and systemic agents against inflammatory skin diseases.<\/jats:p>","DOI":"10.1002\/biof.1699","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T09:26:42Z","timestamp":1608888402000},"page":"170-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":339,"title":["Luteolin as a modulator of skin aging and inflammation"],"prefix":"10.1002","volume":"47","author":[{"given":"Fabian","family":"Gendrisch","sequence":"first","affiliation":[{"name":"Research Center Skinitial, Department of Dermatology, Medical Center University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp R.","family":"Esser","sequence":"additional","affiliation":[{"name":"Allergy Research Group, Department of Dermatology, Medical Center University of Freiburg  Freiburg 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