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To the influence of aging on human life expectancy, there is essential for new biomarkers which possibly will assistance in recognizing age\u2010associated pathologies. Exosomes, which are cell\u2010secreted nanovesicles, make available a new biomarker detection and therapeutic approach for the transfer of different molecules with high capacity. Recently, non\u2010coding RNAs (ncRNA) which are contained in exosomes have developed as important molecules regulating the complexity of aging and relevant human diseases. The discovery of ncRNA provided perceptions into an innovative regulatory platform that could interfere with cellular senescence. The non\u2010coding transcriptome includes a different of RNA species, spanning from short ncRNAs (&lt;200 nucleotides) to long ncRNAs, that are &gt;200\u2009bp long. Upgraded evidence displays that targeting ncRNAs possibly will influence senescence pathways. In this article, we will address ncRNAs that participated in age\u2010related and cellular senescence diseases. 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