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Deficiencies in individual nutrients have been associated with increased risks for age\u2010related diseases and high intakes and\/or blood concentrations with risk reduction. Nutrition in general and the dietary intake of essential and nonessential biofactors is a major determinant of human health, the risk to develop age\u2010related diseases, and ultimately of mortality in the older population. These biofactors can be a cost\u2010effective strategy to prevent or, in some cases, even treat age\u2010related diseases. Examples reviewed herein include omega\u20103 fatty acids and dietary fiber for the prevention of CVD, \u03b1\u2010tocopherol (vitamin E) for the treatment of biopsy\u2010proven nonalcoholic steatohepatitis, vitamin D for the prevention of neurodegenerative diseases, thiamine and \u03b1\u2010lipoic acid for the treatment of diabetic neuropathy, and the role of folate in cancer epigenetics. This list of potentially helpful biofactors in the prevention and treatment of age\u2010related diseases, however, is not exhaustive and many more examples exist. Furthermore, since there is currently no generally accepted definition of the term <jats:italic>biofactors<\/jats:italic>, we here propose a definition that, when adopted by scientists, will enable a harmonization and consistent use of the term in the scientific literature.<\/jats:p>","DOI":"10.1002\/biof.1728","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T02:04:37Z","timestamp":1616810677000},"page":"522-550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The role of biofactors in the prevention and treatment of age\u2010related diseases"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7548-5829","authenticated-orcid":false,"given":"Jan","family":"Frank","sequence":"first","affiliation":[{"name":"University of Hohenheim, Institute of Nutritional Sciences  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Kisters","sequence":"additional","affiliation":[{"name":"Medical Clinic I, St. Anna\u2010Hospital &amp; ESH Excellence Centre  Herne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ovidiu Alin","family":"Stirban","sequence":"additional","affiliation":[{"name":"Sch\u00f6n Klinik N\u00fcrnberg F\u00fcrth  F\u00fcrth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"Obeid","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Laboratory Medicine Saarland University Hospital  Homburg\/Saar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Lorkowski","sequence":"additional","affiliation":[{"name":"Institute of Nutritional Sciences Friedrich Schiller University Jena  Jena Germany"},{"name":"Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle\u2010Jena\u2010Leipzig  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Wallert","sequence":"additional","affiliation":[{"name":"Institute of Nutritional Sciences Friedrich Schiller University Jena  Jena Germany"},{"name":"Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle\u2010Jena\u2010Leipzig  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Egert","sequence":"additional","affiliation":[{"name":"University of Hohenheim, Institute of Nutritional Medicine  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren C.","family":"Podszun","sequence":"additional","affiliation":[{"name":"University of Hohenheim, Institute of Nutritional Sciences  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter P.","family":"Eckert","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, Laboratory for Nutrition in Prevention and Therapy Justus\u2010Liebig\u2010University of Giessen  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline A.","family":"Pettersen","sequence":"additional","affiliation":[{"name":"Northern Medical Program University of Northern British Columbia  Prince George Canada"},{"name":"Division of Neurology, Department of Medicine University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Venturelli","sequence":"additional","affiliation":[{"name":"University of Hohenheim, Institute of Nutritional Sciences  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Georg","family":"Classen","sequence":"additional","affiliation":[{"name":"University of Hohenheim, Institute of Nutritional Sciences  Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Golombek","sequence":"additional","affiliation":[{"name":"W\u00f6rwag Pharma GmbH &amp; Co. 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