{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:22:02Z","timestamp":1776399722349,"version":"3.51.2"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11902058"],"award-info":[{"award-number":["11902058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11532004"],"award-info":[{"award-number":["11532004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11802096"],"award-info":[{"award-number":["11802096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002369","name":"Chongqing University","doi-asserted-by":"publisher","award":["CQKLBST\u20102018\u2010005"],"award-info":[{"award-number":["CQKLBST\u20102018\u2010005"]}],"id":[{"id":"10.13039\/501100002369","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["cstc2019jcyj\u2010bshX0059"],"award-info":[{"award-number":["cstc2019jcyj\u2010bshX0059"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Insufficient attention has been focused on the directional migration of SOX10+ tendon stem cells (STSCs) during tendon remodeling. Here, we investigate whether tenascin\u2010C (TNC) promotes STSC motility and migration. Based on the hypothesis that TNCs induce STSC migration, RNA\u2010sequencing (RNA\u2010seq) was conducted, identifying 2107 differentially expressed genes (DEGs), of which 1272 were up\u2010regulated and 835 down\u2010regulated following treatment with TNC versus the control. The DEGs were principally involved in cell adhesion and cell membrane signal transduction. Highly enriched\u2010related signaling included the PI3K\u2010Akt, focal adhesion, and ECM\u2013receptor interaction pathways. Protein interaction analysis established that TNC was positively correlated with ITGA9 (integrin\u2010\u03b19). Furthermore, TNC activated the phosphorylation levels of FAK and Akt, and knockdown of ITGA9 with siRNA revealed that TNC contributes to STSC migration via the targeting of ITGA9. In addition, in vivo administration of TNC promoted tissue regeneration of injured tendons. In conclusion, TNC regulated the migration of STSCs via ITGA9, thereby promoting the regeneration of tendon injuries.<\/jats:p>","DOI":"10.1002\/biof.1759","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T04:48:18Z","timestamp":1622522898000},"page":"768-777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["<scp>Tenascin\u2010C<\/scp> regulates migration of <scp>SOX10<\/scp> tendon stem cells via integrin\u2010\u03b19 for promoting patellar tendon remodeling"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8492-2058","authenticated-orcid":false,"given":"Kang","family":"Xu","sequence":"first","affiliation":[{"name":"Hubei Engineering Technology Research Center of Chinese Materia Medica Processing, College of Pharmacy, Hubei University of Chinese Medicine  Wuhan China"},{"name":"Engineering Research Center of Clinical Functional Materials and Diagnosis &amp; Treatment Devices of Zhejiang Province, Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibo","family":"Shao","sequence":"additional","affiliation":[{"name":"National Innovation and Attracting Talents \u201c111\u201d base, Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Xia","sequence":"additional","affiliation":[{"name":"Hubei University of Chinese Medicine, Huangjiahu Hospital  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuna","family":"Qian","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Clinical Functional Materials and Diagnosis &amp; Treatment Devices of Zhejiang Province, Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Hubei Engineering Technology Research Center of Chinese Materia Medica Processing, College of Pharmacy, Hubei University of Chinese Medicine  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianqiong","family":"Liu","sequence":"additional","affiliation":[{"name":"Hubei Engineering Technology Research Center of Chinese Materia Medica Processing, College of Pharmacy, Hubei University of Chinese Medicine  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"National Innovation and Attracting Talents \u201c111\u201d base, Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunli","family":"Wang","sequence":"additional","affiliation":[{"name":"National Innovation and Attracting Talents \u201c111\u201d base, Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22806"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21212"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1630"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-009-0581-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2014.0036"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12614"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2020"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2017.11.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1294\/jes.24.17"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/984146"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.10.015"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.12.028"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-1597"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153305"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314789"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6360"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2015.06.003"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4446-y"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2016.99"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06004"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.3077"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.28830"}],"container-title":["BioFactors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.1759","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/biof.1759","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.1759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T07:20:41Z","timestamp":1721287241000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/biof.1759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,31]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/biof.1759"],"URL":"https:\/\/doi.org\/10.1002\/biof.1759","archive":["Portico"],"relation":{},"ISSN":["0951-6433","1872-8081"],"issn-type":[{"value":"0951-6433","type":"print"},{"value":"1872-8081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,31]]},"assertion":[{"value":"2021-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}