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We aimed to evaluate the factors influencing serum 25\u2010hydroxyvitamin D levels in response to supplementation of vitamin D using a random forest (RF) model. Data were extracted from the survey of ultraviolet intake by nutritional approach study. Vitamin D levels were measured at baseline and at the end of study to evaluate the responsiveness. We examined the relationship between 76 potential influencing factors on vitamin D response using RF. We found several features that were highly correlated to the serum vitamin D response to supplementation by RF including anthropometric factors (body mass index [BMI], free fat mass [FFM], fat percentage, waist\u2010to\u2010hip ratio [WHR]), liver function tests (serum gamma\u2010glutamyl transferase [GGT], total bilirubin, total protein), hematological parameters (mean corpuscular volume [MCV], mean corpuscular hemoglobin concentration [MCHC], hematocrit), and measurement of insulin sensitivity (homeostatic model assessment of insulin resistance). BMI, total bilirubin, FFM, and GGT were found to have a positive relationship and homeostatic model assessment for insulin resistance, MCV, MCHC, fat percentage, total protein, and WHR were found to have a negative correlation to vitamin D concentration in response to supplementation. The accuracy of RF in predicting the response was 93% compared to logistic regression, for which the accuracy was 40%, in the evaluation of the correlation of the components of the data set to serum vitamin D.<\/jats:p>","DOI":"10.1002\/biof.1770","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T16:44:33Z","timestamp":1626540273000},"page":"828-836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Factors determining the serum 25\u2010hydroxyvitamin <scp>D<\/scp> response to vitamin <scp>D<\/scp> supplementation: Data mining approach"],"prefix":"10.1002","volume":"47","author":[{"given":"Zahra","family":"Amiri","sequence":"first","affiliation":[{"name":"Department of Pure Mathematics, Center of Excellence in Analysis on Algebraic Structures (CEAAS) Ferdowsi University of Mashhad  Mashhad Iran"},{"name":"International UNESCO Center for Health\u2010Related Basic Sciences and Human Nutrition Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Nosrati","sequence":"additional","affiliation":[{"name":"International UNESCO Center for Health\u2010Related Basic Sciences and Human Nutrition Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Metabolic Syndrome Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payam","family":"Sharifan","sequence":"additional","affiliation":[{"name":"International UNESCO Center for Health\u2010Related Basic Sciences and Human Nutrition Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of Nutrition, School of Medicine Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Student Research Committee, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Saffar Soflaei","sequence":"additional","affiliation":[{"name":"International UNESCO Center for Health\u2010Related Basic Sciences and Human Nutrition Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5377-729X","authenticated-orcid":false,"given":"Susan","family":"Darroudi","sequence":"additional","affiliation":[{"name":"International UNESCO Center for Health\u2010Related Basic Sciences and Human Nutrition Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamideh","family":"Ghazizadeh","sequence":"additional","affiliation":[{"name":"International UNESCO Center for Health\u2010Related Basic Sciences and Human Nutrition Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Student Research Committee, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Mohammadi Bajgiran","sequence":"additional","affiliation":[{"name":"International UNESCO Center for Health\u2010Related Basic Sciences and Human Nutrition Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahimeh","family":"Moafian","sequence":"additional","affiliation":[{"name":"Department of Pure Mathematics, Center of Excellence in Analysis on Algebraic Structures (CEAAS) Ferdowsi University of Mashhad  Mashhad Iran"},{"name":"International UNESCO Center for Health\u2010Related Basic Sciences and Human Nutrition Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Tayefi","sequence":"additional","affiliation":[{"name":"Norwegian Center for e\u2010health Research University hospital of North Norway  Troms\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elahe","family":"Hasanzade","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdi","family":"Rafiee","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon A.","family":"Ferns","sequence":"additional","affiliation":[{"name":"Division of Medical Education Brighton &amp; 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