{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:31:54Z","timestamp":1792272714243,"version":"4.4.0"},"reference-count":118,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Noscapine has been mentioned as one of the effective drugs with potential therapeutic applications. With few side effects and amazing capabilities, noscapine can be considered different from other opioids\u2010like structure compounds. Since 1930, extensive studies have been conducted in the field of pharmacological treatments from against malaria to control cough and cancer treatment. Furthermore, recent studies have shown that noscapine and some analogues, like 9\u2010bromonoscapine, amino noscapine, and 9\u2010nitronoscapine, can be used to treat polycystic ovaries syndrome, stroke, and other diseases. Given the numerous results presented in this field and the role of different receptors in the therapeutic effects of noscapine, we aimed to review the properties, therapeutic effects, and the role of receptors in the treatment of noscapine.<\/jats:p>","DOI":"10.1002\/biof.1781","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T20:14:55Z","timestamp":1631909695000},"page":"975-991","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Biological and pharmacological activities of noscapine: Focusing on its receptors and mechanisms"],"prefix":"10.1002","volume":"47","author":[{"given":"Fahimeh","family":"Nourbakhsh","sequence":"first","affiliation":[{"name":"Medical Toxicology Research Centre, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad 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