{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:29:20Z","timestamp":1791872960153,"version":"4.3.4"},"reference-count":113,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Teucrium polium<\/jats:italic> has been used in traditional medicine as antifungal, antipyretic, antispasmodic, and antibacterial. It is consumed by many jordanians for the treatment of many diseases. The effects of this plant have been investigated in kidney, liver, and brain. Its antidiabetic, antimicrobial, antioxidant, and anticancer effects have been introduced. Polyphenolic compound, flavonoids, monoterpenes, alkanoides, and essential oils were identified. Several studies revealed that this plant has a hypoglycemic effect and can help to control blood sugar. It was reported that plants containing flavonoids and phenolics compounds exhibit a large array of biological activities like genotoxicity (chromosomal aberrations and sister chromatid exchange) and oxidative stress damage. These phytochemicals are found in herbal and vegetables plants, as well as being reliably protective against oxidative stress damage and lipid peroxidation. In addition, <jats:italic>T. polium<\/jats:italic> has secondary effects on different organs, namely liver, kidney and at high doses this plant becomes toxic. In conclusion, this review investigates many pharmacologicals properties and side effects of <jats:italic>T. polium<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/biof.1782","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T09:58:46Z","timestamp":1638352726000},"page":"952-963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Therapeutics studies and biological properties of <i>Teucrium polium<\/i> (Lamiaceae)"],"prefix":"10.1002","volume":"47","author":[{"given":"Fatma","family":"Rahmouni","sequence":"first","affiliation":[{"name":"Laboratory of Histophysiology of Induced and Developmental Diseases Medicine Faculty of Sfax University  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mongi","family":"Saoudi","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Physiology Sciences Faculty of Sfax University  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Rebai","sequence":"additional","affiliation":[{"name":"Laboratory of Histophysiology of Induced and Developmental Diseases Medicine Faculty of Sfax University  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.08.033"},{"key":"e_1_2_13_3_1","unstructured":"BenabdelkaderT.Biodiversit\u00e9 bioactivit\u00e9 et biosynth\u00e8se des compos\u00e9s terp\u00e9niques volatils des lavandes ail\u00e9es Lavandula stoechassensu lato un complexe d'esp\u00e8ces m\u00e9diterran\u00e9ennes d'int\u00e9r\u00eat pharmacologique (Doctoral dissertation).2012."},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10168730802287994"},{"key":"e_1_2_13_5_1","first-page":"697","article-title":"Chemical analysis and antimicrobial activity of T. polium L. essential oil from eastern Algeria","volume":"2","author":"Lograda T","year":"2014","journal-title":"Open J Adv Drug Deliv"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004903"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2015.1082947"},{"key":"e_1_2_13_8_1","first-page":"2588","article-title":"Composition of the essential oil of Teucrium chamaedrys L.(Lamiaceae) from Turkey","volume":"4","author":"Bagci E","year":"2010","journal-title":"J Med Plants Res"},{"key":"e_1_2_13_9_1","first-page":"609","article-title":"Impact of solvent extraction type on total polyphenols content and biological activity from Tamarix aphylla (L.) karst","volume":"2","author":"Mohammedi Z","year":"2011","journal-title":"Int J Pharm Bio Sci"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn305337c"},{"key":"e_1_2_13_11_1","unstructured":"Ira J Pharm Res"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-013-5473-x"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014715025879"},{"key":"e_1_2_13_14_1","unstructured":"LagnikaL.Etude phytochimique et activit\u00e9 biologique de substances naturelles isol\u00e9es de plantes b\u00e9ninoises. Th\u00e8se de doctorat de l'universit\u00e9 Louis Pasteur.2005"},{"key":"e_1_2_13_15_1","first-page":"227","article-title":"The survey of Teucrium polium toxicity effect on liver and serum lipoproteins in normoglycemic male rats","volume":"8","author":"Shahraki MR","year":"2006","journal-title":"Zahedan J. Res. Med. Sci"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/19390211.2017.1363843"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf990146l"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210793176464"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2008.06.064"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2009.11.004"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf900171d"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10007-007-0010-z"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(90)85421-B"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der082"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318265ee8a"},{"key":"e_1_2_13_26_1","volume-title":"Labiatae family in folk medicine in Iran: from ethnobotany to pharmacology","author":"Naghibi F","year":"2005"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1532-0456(03)00120-0"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10969-005-2827-3"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevB.75.155111"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0108270103017050"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2004.01.005"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)90474-6"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1109\/TEC.2006.878241"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1346\/CCMN.1998.0460510"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2004.12.001"},{"key":"e_1_2_13_36_1","first-page":"897","article-title":"Chemical analysis and antimicrobial activity of Teucrium polium L. essential oil from Western Algeria","volume":"7","author":"Belmekki N","year":"2013","journal-title":"J Med Plants Res."},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-010-0436-1"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2010.487866"},{"key":"e_1_2_13_39_1","first-page":"145","article-title":"Anti\u2010spasmodic and anti\u2010nociceptive effects of Teucrium polium aqueous extract","volume":"10","author":"Parsaee H","year":"2006","journal-title":"Iran Biomed J"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.3923\/jbs.2018.192.200"},{"key":"e_1_2_13_41_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.25518\/0037-9565.6472","article-title":"Activit\u00e9 antibact\u00e9rienne de quatre extraits de Teucrium polium L. du mont de Tessala (Alg\u00e9rie occidentale)","volume":"85","author":"Fertout\u2010Mouri N","year":"2016","journal-title":"Bull. Soc. R. Sci. Liege"},{"key":"e_1_2_13_42_1","first-page":"292","article-title":"Evaluation of pharmacological mechanisms of antinociceptive effect of Teucrium polium on visceral pain in mice. Iranian","volume":"12","author":"Zendehdel M","year":"2011","journal-title":"J Vet Res"},{"key":"e_1_2_13_43_1","first-page":"453","article-title":"The biological effects of Teucrium polium on the severity of primary dysmenorrhea","volume":"3","author":"Abadian K","year":"2017","journal-title":"J Appl Biotech Rep"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/493729"},{"key":"e_1_2_13_45_1","first-page":"1259","article-title":"Evaluation of diuretic activity from T. polium L. capitatum extracts (Lamiaceae) in rats","volume":"5","author":"Malki S","year":"2014","journal-title":"Int J Pharm Sci Res"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijpvm.IJPVM_100_17"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12298-017-0444-9"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/726724"},{"key":"e_1_2_13_49_1","first-page":"292","article-title":"Relationship between antioxidant properties and phenolics in Zhumeria majdae","volume":"2","author":"Moein S","year":"2010","journal-title":"J Med Plants Res"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.03.006"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1261"},{"key":"e_1_2_13_52_1","first-page":"938324","article-title":"The effect of an aqueous extract of Teucrium polium on glutathione homeostasis in vitro: a possible mechanism of its hepatoprotectant action","volume":"2010","author":"Shtukmaster S","year":"2010","journal-title":"Adv Pharmacol Sci"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1380"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2010.10.006"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2012.06.025"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2014.06.037"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(10)60050-8"},{"key":"e_1_2_13_58_1","unstructured":"MansouriS CosofretV XuC.U.S.Patent No. 7 455 760.Washington DC:U.S. Patent and Trademark Office.2008."},{"key":"e_1_2_13_59_1","volume-title":"Herbal medicine expanded commission E monographs","author":"Blumenthal M","year":"2000"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(01)00196-9"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.5897\/AJPP11.246"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2014.03.029"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nonrwa.2007.05.005"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.4617"},{"key":"e_1_2_13_65_1","first-page":"302","article-title":"Hepatoprotective activity of methanol extract of some medicinal plants against carbon tetrachloride\u2010induced hepatotoxicity in rats","volume":"37","author":"Ahsan MR","year":"2009","journal-title":"Eur J Sci Res"},{"key":"e_1_2_13_66_1","first-page":"295","article-title":"Donor liver steatosis and graft selection for liver transplantation: a short review","volume":"9","author":"Angelico M","year":"2005","journal-title":"Eur Review Med Pharmacol Sci"},{"key":"e_1_2_13_67_1","first-page":"1330","article-title":"Hepatoprotective activity of some indigenous plants","volume":"4","author":"Bhawna S","year":"2009","journal-title":"Int J Pharm Tech Res"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2018.1519864"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2017.1347795"},{"key":"e_1_2_13_70_1","first-page":"7","article-title":"The inotropic and chronotropic effects of aqueous ethanolic extract from Teucrium polium L. on guinea pig isolated heart","volume":"10","author":"Niazmand SAEID","year":"2008","journal-title":"J Babol Univ Med Sci"},{"key":"e_1_2_13_71_1","first-page":"60","article-title":"The effects of aqueous extract from Teucrium polium L. on rat gastric motility in basal and vagal\u2010stimulated conditions","volume":"1","author":"Niazmand S","year":"2007","journal-title":"Iran. J. Basic Med. Sci."},{"key":"e_1_2_13_72_1","first-page":"347","article-title":"Effects of Teucrium polium ethyl acetate extract on serum, liver and muscle triglyceride content of sucrose\u2010induced insulin resistance in rat","volume":"11","author":"Mousavi SE","year":"2012","journal-title":"Iran J Pharmaceut Research"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1556\/APhysiol.94.2007.3.10"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.04.071"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2008.09.086"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458515604383"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-012-9527-1"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-4269-1-6"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.10.026"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1088\/0953-8984\/24\/23\/235503"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069494"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957864"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/1071576031000068618"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultras.2008.04.005"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2014.07.013"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/2193-1801-2-587"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.12.008"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1142\/S1758825117500879"},{"key":"e_1_2_13_89_1","first-page":"133","article-title":"Methanolic extract of Teucrium polium L. potentiates the cytotoxic and apoptotic effects of anticancer drugs of vincristine, vinblastine and doxorubicin against a panel of cancerous cell lines","volume":"30","author":"Rajabalian S","year":"2008","journal-title":"Exp Oncol"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880200701214904"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1449"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2017.11.113"},{"key":"e_1_2_13_93_1","first-page":"63","article-title":"Total phenolic content, flavonoid concentration and antioxidant activity of Marrubium peregrinum L. extracts","volume":"3","author":"Stankovic MS","year":"2011","journal-title":"Kragujevac J Sci"},{"key":"e_1_2_13_94_1","doi-asserted-by":"crossref","unstructured":"MahdiniaP BerenjkoobM VatankhahH.Attack signature matching using graphics processors in high\u2010performance intrusion detection systems. In2013 21st Iranian Conference on Electrical Engineering (ICEE)(pp. 1\u20137). IEEE.2013","DOI":"10.1109\/IranianCEE.2013.6599567"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.21608\/jcbr.2019.34741"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.13-1-7"},{"key":"e_1_2_13_97_1","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.15376\/biores.6.3.2732-2743","article-title":"Comparative studies of physical characteristics of raw and modified sawdust for their use as adsorbents for removal of acid dye","volume":"6","author":"Singh J","year":"2011","journal-title":"Biores"},{"key":"e_1_2_13_98_1","first-page":"387","article-title":"Severe acute cholestasis caused by Teucrium polium","volume":"18","author":"Mimidis KP","year":"2009","journal-title":"J Gastrointes Liver Dis"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327116688069"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntx135"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.fluid.36.050802.122132"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.11.013"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200606000-00016"},{"key":"e_1_2_13_104_1","first-page":"106","article-title":"Hepatotoxicity of 'Teucrium polium' L. tea: supporting evidence in mice models","volume":"21","author":"Abu Sitta KH","year":"2009","journal-title":"Aust J Med Herb"},{"key":"e_1_2_13_105_1","first-page":"1331","article-title":"Hepatoprotective activity of hydro\u2010alcoholic extracts of Iranian Teucrium polium","volume":"3","author":"Parna Z","year":"2014","journal-title":"World J Pharm Res"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intmar.2011.01.003"},{"key":"e_1_2_13_107_1","first-page":"72","article-title":"Herbal hepatotoxicity in traditional and modern medicine: actual key issues and new encouraging steps","volume":"6","author":"Eschke R","year":"2015","journal-title":"Front Pharmacol"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.18433\/J36G6X"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1061\/(ASCE)CC.1943-5614.0000256"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10718"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2014.5415"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.5812\/nephropathol.12116"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02050309"},{"key":"e_1_2_13_114_1","unstructured":"ANSMPS: Agence Nationale de Securite de Medicament et des Produit de Sante2015.Liste B des plantes m\u00e9dicinales utilis\u00e9es traditionnellement.http:\/\/ansm.sante.fr\/var\/ansm_site\/storage\/original\/application\/6.PDF. Consult\u00e9e le 12 avril 2018."}],"container-title":["BioFactors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.1782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/biof.1782","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.1782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T06:24:49Z","timestamp":1693203889000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/biof.1782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":113,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1002\/biof.1782"],"URL":"https:\/\/doi.org\/10.1002\/biof.1782","archive":["Portico"],"relation":{},"ISSN":["0951-6433","1872-8081"],"issn-type":[{"value":"0951-6433","type":"print"},{"value":"1872-8081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"2021-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}