{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:06:13Z","timestamp":1787753173234,"version":"build-2784847793"},"reference-count":170,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["284155"],"award-info":[{"award-number":["284155"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Renal cell carcinoma (RCC) is one of the most lethal urological cancers, highly resistant to chemo and radiotherapy. Obesity and smoking are the best\u2010known risk factors of RCC, both related to oxidative stress presence, suggesting a significant role in RCC development and maintenance. Surgical resection is the treatment of choice for localized RCC; however, this neoplasia is hardly diagnosable at its initial stages, occurring commonly in late phases and even when metastasis is already present. Systemic therapies are the option against RCC in these more advanced stages, such as cytokine therapy or a combination of tyrosine kinase inhibitors with immunotherapies; nevertheless, these strategies are still insufficient. A field poorly analyzed in this neoplasia is the status of cell signaling pathways sensible to the redox state, which have been associated with the development and maintenance of RCC. This review focuses on alterations reported in the following redox\u2010sensitive molecules and signaling pathways in RCC: mitogen\u2010activated protein kinases, protein kinase B (AKT)\/tuberous sclerosis complex 2\/mammalian target of rapamycin C1, AKT\/glycogen synthase kinase 3\/\u03b2\u2010catenin, nuclear factor \u03baB\/inhibitor of \u03baB\/epidermal growth factor receptor, and protein kinase C\u03b6\/cut\u2010like homeodomain protein\/factor inhibiting hypoxia\u2010inducible factor (HIF)\/HIF as potential targets for redox therapy.<\/jats:p>","DOI":"10.1002\/biof.1784","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T13:07:00Z","timestamp":1633007220000},"page":"342-358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Redox\u2010sensitive signaling pathways in renal cell carcinoma"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0077-5079","authenticated-orcid":false,"given":"Alfredo","family":"Cruz\u2010Gregorio","sequence":"first","affiliation":[{"name":"Laboratorio F\u2010225, Departamento de Biolog\u00eda, Facultad de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4095-754X","authenticated-orcid":false,"given":"Ana Karina","family":"Aranda\u2010Rivera","sequence":"additional","affiliation":[{"name":"Laboratorio F\u2010315, Departamento de Biolog\u00eda, Facultad de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6628-4411","authenticated-orcid":false,"given":"Jos\u00e9","family":"Pedraza\u2010Chaverri","sequence":"additional","affiliation":[{"name":"Laboratorio F\u2010315, Departamento de Biolog\u00eda, Facultad de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 D.","family":"Solano","sequence":"additional","affiliation":[{"name":"Laboratorio F\u2010225, Departamento de Biolog\u00eda, Facultad de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1076-6248","authenticated-orcid":false,"given":"Mar\u00eda Elena","family":"Ibarra\u2010Rubio","sequence":"additional","affiliation":[{"name":"Laboratorio F\u2010225, Departamento de Biolog\u00eda, Facultad de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.9"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2016.08.006"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.0100"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7511"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12222"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2015.05.008"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.07.014"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101109"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2017.08.010"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.10.7.13247"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006098"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1684\/bdc.2010.1066"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520060404"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2010.12.016"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2005.12.009"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2018.01.003"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3365"},{"key":"e_1_2_15_20_1","doi-asserted-by":"crossref","unstructured":"Cruz\u2010GregorioA Mart\u00ednez\u2010Ram\u00edrezI Pedraza\u2010ChaverriJ LizanoM.Reprogramming of energy metabolism in response to radiotherapy in head and neck squamous cell carcinoma cancers (Basel).2019;11.https:\/\/doi.org\/10.3390\/cancers11020182","DOI":"10.3390\/cancers11020182"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3801"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.07.001"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199812)186:4<416::AID-PATH201>3.0.CO;2-U"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12374036"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.106.077073"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-014-0446-0"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.06.009"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.101084"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5234.296"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.05.034"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0230-3"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.12.035"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2230"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2256"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00224"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.159814"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-012-0878-z"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2008.01.021"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi901221s"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.03.038"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.11.013"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.05.040"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.05.004"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.12.011"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R113.467738"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(85)90442-7"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6385"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1089\/152308603770310239"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi401700f"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2016.09.011"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3036"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.15.6391-6403.2005"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2013.790873"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.05.016"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/stke.2000.53.pe1"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1089\/152308603770380070"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311370200"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.13.8516"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.1.217"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11670-010-0087-7"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.5772\/26747"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1997.363"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.5.909"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr315"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-010-0437-2"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i3.446"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.07.030"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/10937400701436460"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22386"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2003.08.017"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.8.11.1751"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.01.022"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5311"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.3109\/10799893.2015.1030412"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011254"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2374"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.12.012"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8170-7"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2006.11.001"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290105"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E05-12-1104"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2008.05.001"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2018.01.008"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21403"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28864"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.121896"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413985200"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.020875"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.08.472"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24389"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.01.071"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2020.5041"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13061441"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.12.041"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00043-14"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0955-0674(98)80143-9"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi992410"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210410"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1209"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.4989"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2566-1"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290257"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.12.013"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.02.004"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.2.4.433"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-019-0229-8"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kve046"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.31232"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2007.06.007"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.04.001"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011189"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1106148"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200665200"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.07.015"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200507119"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-020-00416-0"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2011.96"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111899200"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg513"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32579"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-7-10"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-2187-4-8"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090606"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.333"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.05.012"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.304"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011163"},{"key":"e_1_2_15_128_1","unstructured":"The Wnt Homepage.Wnt Target genes[cited 2019 Sept 4]. Available from:https:\/\/web.stanford.edu\/group\/nusselab\/cgi-bin\/wnt\/target_genes"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.231944.113"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070741"},{"key":"e_1_2_15_131_1","first-page":"460","article-title":"Altered expression of beta\u2010catenin in renal cell cancer and transitional cell cancer with the absence of beta\u2010catenin gene mutations","volume":"6","author":"Bilim V","year":"2000","journal-title":"Clin Cancer Res"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15361"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.178"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076746"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/24.3.377"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-27-53"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.21.13245"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1991.tb07761.x"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040727"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01576-2"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.09.022"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.3109\/10409238.2013.838205"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040620"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059817"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.03.001"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312254200"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.924501"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2015.05.007"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00224"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-805421-5.00002-1"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611569200"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2105"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2706"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02201-06"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.22.6573"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200273200"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.23.14.4959-4971.2003"},{"key":"e_1_2_15_158_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00660.x"},{"key":"e_1_2_15_159_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1998.tb00633.x"},{"key":"e_1_2_15_160_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-016-0463-4"},{"key":"e_1_2_15_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00290-9"},{"key":"e_1_2_15_162_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.582273"},{"key":"e_1_2_15_163_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060655"},{"key":"e_1_2_15_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.02.038"},{"key":"e_1_2_15_165_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-07-2400"},{"key":"e_1_2_15_166_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-015-0694-5"},{"key":"e_1_2_15_167_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5878"},{"key":"e_1_2_15_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2013.06.002"},{"key":"e_1_2_15_169_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2775-2"},{"key":"e_1_2_15_170_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.5376"},{"key":"e_1_2_15_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1569"}],"container-title":["BioFactors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.1784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/biof.1784","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.1784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T17:12:44Z","timestamp":1692983564000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/biof.1784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,30]]},"references-count":170,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/biof.1784"],"URL":"https:\/\/doi.org\/10.1002\/biof.1784","archive":["Portico"],"relation":{},"ISSN":["0951-6433","1872-8081"],"issn-type":[{"value":"0951-6433","type":"print"},{"value":"1872-8081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,30]]},"assertion":[{"value":"2021-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}