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Macrophage apoptosis plays a significant role in the development of atherosclerotic plaque. We aimed to explore the effect of thyroid hormones on macrophage apoptosis induced by oxidized low\u2010density lipoprotein (oxLDL). Peripheral blood samples from 20 patients (normal group, hypothyroidism group, coronary artery disease [CAD] group, hypothyroidism\u2009+\u2009CAD group) were collected to perform messenger RNA microarray analysis. Bioinformatics analysis identified apoptosis and mitogen\u2010activated protein kinase (MAPK) signaling as differentially expressed pathways between CAD and hypothyroidism + CAD group. In vitro, thyroid hormones concentration\u2010dependently promoted cell survival and inhibited apoptosis in oxLDL\u2010treated RAW264.7 macrophages, along with elevated extracellular signal\u2010regulated kinases 1 and 2 (Erk1\/2) phosphorylation. The STRING database showed an interaction of thyroid hormone receptor alpha1 (TR\u03b11) and MAPK pathway. TR\u03b11 knockdown increased cell apoptosis and decreased Erk1\/2 phosphorylation. Erk1\/2 inhibitor aggravated macrophage apoptosis. Moreover, thyroid hormones inhibited oxidative stress in oxLDL\u2010treated macrophages. The study indicates that thyroid hormones concentration\u2010dependently attenuate oxLDL\u2010induced macrophage apoptosis through activating TR\u03b11\u2010Erk1\/2 pathway and inhibiting oxidative stress, which implies a potential mechanism of hypothyroid\u2010accelerated atherosclerosis.<\/jats:p>","DOI":"10.1002\/biof.1803","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T15:21:20Z","timestamp":1639063280000},"page":"86-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Thyroid hormones inhibit apoptosis of macrophage induced by oxidized low\u2010density lipoprotein"],"prefix":"10.1002","volume":"48","author":[{"given":"Yu","family":"Ning","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"National Health Commission Key Laboratory of Assisted Circulation Sun 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