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Among the underlying causes, certainly a reduced dietary intake and\/or poor absorption in the gastrointestinal tract play a key role in decreasing their bioavailability. Recent evidence from clinical and in vivo studies suggests an increasingly important contribution from the gut microbiome. Commensal microorganisms can in fact regulate the levels of micronutrients, both by intervening in the biosynthetic processes and by modulating their absorption. This short narrative review addresses the pivotal role of the gut microbiome in influencing the bioavailability of vitamins (such as A, B, C, D, E, and K) and minerals (calcium, iron, zinc, magnesium, and phosphorous), as well as the impact of these micronutrients on microbiome composition and functionality. Personalized microbiome\u2010based intervention strategies could therefore constitute an innovative tool to counteract micronutrient deficiencies by modulating the gut microbiome toward an eubiotic configuration capable of satisfying the needs of our organism, while promoting general health.<\/jats:p>","DOI":"10.1002\/biof.1835","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T14:01:48Z","timestamp":1647439308000},"page":"307-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":154,"title":["Gut microbiome\u2013micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5229-570X","authenticated-orcid":false,"given":"Monica","family":"Barone","sequence":"first","affiliation":[{"name":"Microbiomics Unit, Department of Medical and Surgical Sciences University of Bologna  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