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Applying a novel enzymatic assay, we here identified a methanethiol oxidase (MTO) that catalyzes the degradation of methanethiol in the nematode <jats:italic>Caenorhabditis elegans<\/jats:italic> (<jats:italic>C. elegans<\/jats:italic>). The corresponding protein, Y37A1B.5, previously characterized as a <jats:italic>C. elegans<\/jats:italic> ortholog of human selenium\u2010binding protein 1 (SELENBP1), was renamed SEMO\u20101 (SELENBP1 ortholog with methanethiol oxidase activity). Worms rendered deficient in SEMO\u20101 not only showed decreased hydrogen sulfide production from methanethiol catabolism but they were also more resistant to oxidative stress and had an elevated life span. In contrast, resistance to selenite was significantly lowered in SEMO\u20101\u2010deficient worms. Naturally occurring mutations of human SELENBP1 were introduced to recombinant SEMO\u20101 through site\u2010directed mutagenesis and resulted in loss of its MTO activity, indicating a similar enzymatic mechanism for SELENBP1 and SEMO\u20101. In summary, SEMO\u20101 confers resistance to toxic selenite and the ability to metabolize toxic methanethiol. These beneficial effects might be a trade\u2010off for its negative impact on <jats:italic>C. elegans<\/jats:italic> life span.<\/jats:p>","DOI":"10.1002\/biof.1836","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T13:47:59Z","timestamp":1647956879000},"page":"699-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["<scp>SEMO<\/scp>\u20101, a novel methanethiol oxidase in <i>Caenorhabditis elegans<\/i>, is a pro\u2010aging factor conferring selective stress resistance"],"prefix":"10.1002","volume":"48","author":[{"given":"Thilo Magnus","family":"Philipp","sequence":"first","affiliation":[{"name":"Institute of Nutritional Sciences, Nutrigenomics Section Friedrich Schiller University Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiye","family":"Gong","sequence":"additional","affiliation":[{"name":"Institute of Nutritional Sciences, 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