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Morin effects on rat liver and brain were evaluated post\u2010induction of HE by thioacetamide (TAA; 200\u2009mg\/kg\/day for 3 successive days). Then, the serum activities of aspartate transaminase (AST) and alanine transaminase (ALT) together with ammonia concentration were estimated to assess the liver function. Also, the degree of brain effects was evaluated via the assessment of brain contents of reduced glutathione (GSH), malondialdehyde (MDA), tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), and interleukin (IL\u20101\u03b2) together with glutathione peroxidase (GPx) activity. In addition, the apoptotic and inflammatory changes in brain and liver tissues were also assessed via immunohistochemical examination. Our findings revealed a promising effect of morin against HE complications; as it corrected the liver functions, attenuated the brain\/liver tissue injuries, and reduced the apoptotic and inflammatory insults of HE on both organs. These effects are comparable to those of silymarin. Morin could be introduced as a promising hepato\u2010 and neuro\u2010therapeutic adjuvant in HE\u2010associated neuronal complications especially in cases like silymarin intolerance.<\/jats:p>","DOI":"10.1002\/biof.1838","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T10:05:37Z","timestamp":1648202737000},"page":"1166-1178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Molecular mechanisms involved in the effects of morin in experimental hepatic encephalopathy"],"prefix":"10.1002","volume":"48","author":[{"given":"Ghada M.","family":"Shafey","sequence":"first","affiliation":[{"name":"Drug Radiation Research Department National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6593-378X","authenticated-orcid":false,"given":"Engy R.","family":"Rashed","sequence":"additional","affiliation":[{"name":"Drug Radiation Research Department National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala F.","family":"Zaki","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Department, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina S.","family":"Attia","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Department, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona A.","family":"El\u2010Ghazaly","sequence":"additional","affiliation":[{"name":"Drug Radiation Research Department National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Saucedo.Harmful use of alcohol: alcohol use disorders and alcoholic liver diseases. 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