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Inflammatory and allergic mediators released by dendritic and mast cells within the conjunctiva cause allergic conjunctivitis (AC), a prevalent ocular surface disorder that affects &gt;40% of the world's human population on a seasonal or perennial basis. Even though histamine is a major culprit, platelet\u2010activating factor (PAF) also contributes to AC, acting either directly or synergistically with histamine and other mediators. PAF receptor\u2010meditated inflammatory reactions, via cell\u2010membrane\u2010bound and nuclear\u2010membrane\u2010bound and nuclear PAF receptors, are also implicated in the etiology of other eye diseases such as uveitis, diabetic retinopathy, corneal and choroidal neovascularization, and age\u2010related macular degeneration which cause serious visual impairment and can lead to blindness. This review highlights the various deleterious elements implicated in the pathological aspects of ocular allergic reactions and inflammation and provides concepts and treatment options to mitigate these eye disorders with a special focus on PAF and PAF receptor antagonists.<\/jats:p>","DOI":"10.1002\/biof.1848","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T15:24:17Z","timestamp":1653060257000},"page":"1226-1249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<scp>PAF<\/scp>\u2010induced inflammatory and immuno\u2010allergic ophthalmic diseases and their mitigation with <scp>PAF<\/scp> receptor antagonists: Cell and nuclear effects"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4432-730X","authenticated-orcid":false,"given":"Najam A.","family":"Sharif","sequence":"first","affiliation":[{"name":"Singapore Eye Research Institute (SERI)  Singapore Singapore"},{"name":"Department of Pharmacology and Neuroscience University of North Texas Health Sciences Center  Fort Worth Texas USA"},{"name":"Department of Pharmacy Sciences Creighton University  Omaha Nebraska USA"},{"name":"Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences Texas Southern University  Houston Texas USA"},{"name":"Department of Surgery &amp; Cancer Imperial College of Science and Technology  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,20]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"WHO2018;Blindness and vision impairment. 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