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Intake of carbohydrates (CHO), particularly a sugary diet that rapidly increases blood glucose, triglycerides, and blood pressure levels is the predominant determining factor of MetS. Complex CHO, on the other hand, are a stable source of energy taking a longer time to digest. In particular, resistant starch (RS) or soluble fiber is an excellent source of prebiotics, which alter the gut microbial composition, which in turn improves metabolic control. Altering maternal CHO intake during pregnancy may result in the child developing MetS. Furthermore, lifestyle factors such as physical inactivity in combination with dietary habits may synergistically influence gene expression by modulating genetic and epigenetic regulators transforming childhood obesity into adolescent metabolic disorders. This review summarizes the common pathophysiology of MetS in connection with the nature of CHO, intrauterine nutrition, genetic predisposition, lifestyle factors, and advanced treatment approaches; it also emphasizes how dietary CHO may act as a key element in the pathogenesis and future therapeutic targets of obesity and MetS.<\/jats:p>","DOI":"10.1002\/biof.1886","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T09:45:25Z","timestamp":1663148725000},"page":"1036-1059","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Dietary carbohydrates: Pathogenesis and potential therapeutic targets to obesity\u2010associated metabolic syndrome"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-5879","authenticated-orcid":false,"given":"Salima","family":"Akter","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology School of Medicine, Kyung Hee University Seoul 02447 Republic of Korea"},{"name":"Department of Medical Biotechnology Bangladesh University of Health Sciences Dhaka 1216 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajara","family":"Akhter","sequence":"additional","affiliation":[{"name":"Biomedical and Toxicological Research Institute, Bangladesh Council of Scientific and Industrial Research (BCSIR) Dhaka 1205 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib Sadat","family":"Chaudhury","sequence":"additional","affiliation":[{"name":"Department of Biochemistry International Medical College Hospital Tongi 1711 Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-3149","authenticated-orcid":false,"given":"MD. 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