{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:29:09Z","timestamp":1790195349034,"version":"4.1.0"},"reference-count":122,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["iubmb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This review aimed to identify preclinical and clinical studies examining the effects of rosmarinic acid (RA), carnosic acid (CaA), rosmanol (RO), carnosol (CA), and ursolic acid (UA) against allergic and immunologic disorders. Various online databases, including PubMed, Science Direct, EMBASE, Web of Sciences, Cochrane trials, and Scopus, were searched from inception until October 2022. Due to the suppression of the nuclear factor\u2010\u03baB (NF\u2010\u03baB) pathway, the main factor in allergic asthma, RA may be a promising candidate for the treatment of asthma. The other ingredients comprising CA and UA reduce the expression of interleukin (IL)\u20104, IL\u20105, and IL\u201013 and improve airway inflammation. Rosemary's anti\u2010cancer effect is mediated by several mechanisms, including DNA fragmentation, apoptosis induction, inhibition of astrocyte\u2010upregulated gene\u20101 expression, and obstruction of cell cycle progression in the G1 phase. The compounds, essentially found in Rosemary essential oil, prevent smooth muscle contraction through its calcium antagonistic effects, inhibiting acetylcholine (ACH), histamine, and norepinephrine stimulation. Additionally, CA exhibits a substantially greater interaction with the nicotinic ACH receptor than a family of medications that relax the smooth muscles, making it a potent antispasmodic treatment. The components have demonstrated therapeutic effects on the immune, allergy, and respiratory disorders.<\/jats:p>","DOI":"10.1002\/biof.1929","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T01:43:21Z","timestamp":1671846201000},"page":"478-501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Effects of rosmarinic acid, carnosic acid, rosmanol, carnosol, and ursolic acid on the pathogenesis of respiratory diseases"],"prefix":"10.1002","volume":"49","author":[{"given":"Faegheh","family":"Farhadi","sequence":"first","affiliation":[{"name":"Herbal and Traditional Medicines Research center Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2320-5095","authenticated-orcid":false,"given":"Vafa","family":"Baradaran Rahimi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Mohamadi","sequence":"additional","affiliation":[{"name":"Herbal and Traditional Medicines Research center Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9268-6270","authenticated-orcid":false,"given":"Vahid Reza","family":"Askari","sequence":"additional","affiliation":[{"name":"International UNESCO Center for Health\u2010Related Basic Sciences and Human Nutrition Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Applied Biomedical Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2016.05.013"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2018.07.015"},{"key":"e_1_2_9_4_1","first-page":"165","article-title":"Cytotoxicity and apoptogenic properties of the standardized extract of Portulaca oleracea on glioblastoma multiforme cancer cell line (U\u201087): a mechanistic study","volume":"18","author":"Baradaran Rahimi V","year":"2019","journal-title":"EXCLI J"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112706"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10132889"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.07.084"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116595"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2021.07.005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1118-3918"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7969422"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061739"},{"key":"e_1_2_9_13_1","unstructured":"M.Al\u2010Sereiti K.Abu\u2010Amer P.Sena(1999)Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb1961.47.521"},{"key":"e_1_2_9_15_1","first-page":"1525","article-title":"Anti\u2010proliferative and anti\u2010oxidant properties of rosemary Rosmarinus officinalis","volume":"17","author":"Cheung S","year":"2007","journal-title":"Oncol Rep"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.10.039"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.07.005"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.38001\/ijlsb.693371"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.postharvbio.2022.111868"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicines5030098"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-63.10.1359"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8110731"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(91)90161-6"},{"key":"e_1_2_9_24_1","first-page":"49","article-title":"Antidiarrheal effects of rosemary oil (rosemarinus officinalis)","volume":"1","author":"Ibrar M","year":"2004","journal-title":"Inti Chon Pharm Med"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209209054014"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2009.09.012"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.132795"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21609"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2018.04.004"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.01.033"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105923"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.10.010"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21060769"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.11.033"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2020.050"},{"key":"e_1_2_9_36_1","first-page":"399","article-title":"Effects of Rosmarinus officinalis and Platanus orientalis extracts on asthmatic subjects resistant to routine treatments","volume":"8","author":"Mirsadraee M","year":"2018","journal-title":"Avicenna J Phytomed"},{"key":"e_1_2_9_37_1","first-page":"819","article-title":"Effects of diterpene phenol extract of Rosmarinus officinalis on TGFbeta1 and mRNA expressions of its signaling pathway molecules in the lung tissue of pulmonary fibrosis rats","volume":"33","author":"Yang L\u2010T","year":"2013","journal-title":"Chin J Integr Tradit Western Med"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2016.1247881"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2020.1826991"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184368"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01264-3"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6584"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.12691\/jfnr-10-2-4"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-68.4.790"},{"key":"e_1_2_9_45_1","first-page":"130","article-title":"Effect of sub\u2010inhibitory and inhibitory concentrations of some antibiotics and rosemary essential oil (Rosmarinus officinalis L.) on biofilm formation of Klebsiella pneumoniae","volume":"4","author":"Abdulhasan G","year":"2016","journal-title":"World J Exp Biosci"},{"key":"e_1_2_9_46_1","first-page":"68","article-title":"Potential use of rosemary (Rosmarinus officinalis L.) essential oil as anti\u2010bacterial and anti\u2010algal","volume":"12","author":"Najem AM","year":"2017","journal-title":"Pharm Biol Sci"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1639726"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2004.10.009"},{"key":"e_1_2_9_49_1","volume-title":"Effect of rosemary (Rosmarinus officinalis L.) tissue extracts on the growth of some skin infectious microorganisms","year":"2009"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-10-303"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370216688571"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2017.10.006"},{"key":"e_1_2_9_53_1","first-page":"6","article-title":"Anti\u2010microbial activity of carnosic acid isolated from Rosmarinus officinalis L. leaves","volume":"16","author":"Al\u2010Bayati FA","year":"2011","journal-title":"Tikrit J Pure Sci"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X1300801223"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2017.04.010"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA05268C"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.03.038"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2022.04.012"},{"key":"e_1_2_9_59_1","first-page":"54","article-title":"Potential of rosemary oil to be used in drug\u2010resistant infections","volume":"13","author":"Luqman S","year":"2007","journal-title":"Altern Ther Health Med"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-020-00083-5"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2015.10.002"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2019.1572182"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3A0320-434R"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.05.023"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.03.030"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110568"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892420953351"},{"key":"e_1_2_9_68_1","first-page":"1203","article-title":"Beneficial effects of rosmarinic acid on suppression of collagen induced arthritis","volume":"30","author":"Youn J","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13602"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf104837w"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.12.049"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.08.085"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO01928A"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/690346"},{"key":"e_1_2_9_75_1","first-page":"1","article-title":"Toxicological evaluations of betulinic acid and ursolic acid; common constituents of Houttuynia cordata used as an anthelmintic by the Naga tribes in north\u2010East India","volume":"7","author":"Mishra V","year":"2021","journal-title":"Future J Pharm Sci"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.09.038"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-017-0438-9"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2000208117"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2005.11.005"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-019-00038-6"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031318"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.05.013"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00370"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-020-07736-1"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.03.023"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2020.1782427"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0389-6"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12335"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.01.001"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2006.pto_401.x"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1177\/1945892420913430"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.02.010"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2014.58"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27010078"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14793"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-010-0166-4"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12010052"},{"key":"e_1_2_9_98_1","first-page":"1","article-title":"Ursolic acid exerts anti\u2010cancer activity by suppressing vaccinia\u2010related kinase 1\u2010mediated damage repair in lung cancer cells","volume":"5","author":"Kim S\u2010H","year":"2015","journal-title":"Sci Rep"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2012.03.012"},{"key":"e_1_2_9_100_1","first-page":"412","article-title":"Carnosic acid exhibits anti\u2010proliferative and proapoptotic effects in tumoral NCI\u2010H460 and nontumoral IMR\u201090 lung cells","volume":"83","author":"Corveloni AC","year":"2020","journal-title":"J Toxicol Environ Health A"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2017.3970"},{"key":"e_1_2_9_102_1","first-page":"907","article-title":"Carnosic acid enhances the anti\u2010lung cancer effect of cisplatin by inhibiting myeloid\u2010derived suppressor cells","volume":"16","author":"Wen L","year":"2018","journal-title":"Chin J Nat Med"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-015-0005-y"},{"key":"e_1_2_9_104_1","first-page":"297","article-title":"Antitumor effects of ursolic acid through mediating the inhibition of STAT3\/PD\u2010L1 signaling in non\u2010small cell lung cancer cells","volume":"9","author":"Kang DY","year":"2021","journal-title":"Biomedicine"},{"key":"e_1_2_9_105_1","first-page":"1816","article-title":"Autophagy inhibition enhances the inhibitory effects of ursolic acid on lung cancer cells","volume":"46","author":"Wang M","year":"2020","journal-title":"Int J Mol Med"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.04.027"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11485"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e328360093b"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17089104"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22891"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2011.04.014"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.07.043"},{"key":"e_1_2_9_113_1","first-page":"175","article-title":"Biological activity of Rosmarinus officinalis and Acacia nilotica: induced apoptosis and DNA damage of A549 lung cancer cell line","volume":"8","author":"Tallima HM","year":"2017","journal-title":"Res J Pharm, Biol Chem Sci"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1709"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-017-0374-8"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.552210125"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2007.0524"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24243"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.05.004"},{"key":"e_1_2_9_120_1","first-page":"315","article-title":"Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house dust mite allergen in mice","volume":"16","author":"Inoue K\u2010I","year":"2005","journal-title":"Int J Mol Med"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2008.00565.x"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1078\/094471103322331421"},{"key":"e_1_2_9_123_1","first-page":"1163","article-title":"In vivo and in vitro biological evaluation of the anti\u2010inflammatory and analgesic response of carnosol and carnosic acid and in silico analysis of their target interactions","volume":"173","author":"Maione F","year":"2016","journal-title":"Br J Pharmacol"}],"container-title":["BioFactors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.1929","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/biof.1929","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.1929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T16:08:27Z","timestamp":1692547707000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/biof.1929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,23]]},"references-count":122,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/biof.1929"],"URL":"https:\/\/doi.org\/10.1002\/biof.1929","archive":["Portico"],"relation":{},"ISSN":["0951-6433","1872-8081"],"issn-type":[{"value":"0951-6433","type":"print"},{"value":"1872-8081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,23]]},"assertion":[{"value":"2022-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}