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Cancer cells may provide some mechanisms to resist oxidative stress and escape from apoptosis and attack by the immune system. Furthermore, cancer cells may resist senescence, pyroptosis, ferroptosis, necroptosis, and autophagic cell death by modulating several critical genes. The development of these mechanisms leads to resistance to anti\u2010cancer drugs and also radiotherapy. Resistance to therapy can increase mortality and reduce survival following cancer therapy. Thus, overcoming mechanisms of resistance to cell death in malignant cells can facilitate tumor elimination and increase the efficiency of anti\u2010cancer therapy. Natural\u2010derived molecules are intriguing agents that may be suggested to be used as an adjuvant in combination with other anticancer drugs or radiotherapy to sensitize cancer cells to therapy with at least side effects. This paper aims to review the potential of triptolide for inducing various types of cell death in cancer cells. We review the induction or resistance to different cell death mechanisms such as apoptosis, autophagic cell death, senescence, pyroptosis, ferroptosis, and necrosis following the administration of triptolide. We also review the safety and future perspectives for triptolide and its derivatives in experimental and human studies. The anticancer potential of triptolide and its derivatives may make them effective adjuvants for enhancing tumor suppression in combination with anticancer therapy.<\/jats:p>","DOI":"10.1002\/biof.1944","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T09:35:35Z","timestamp":1678095335000},"page":"718-735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Mechanisms of cancer cell death induction by triptolide"],"prefix":"10.1002","volume":"49","author":[{"given":"Ali Hamid","family":"AbdulHussein","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy University of Al\u2010Ameed Karbala Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muataz Mohammed","family":"Al\u2010Taee","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratories Technology AL\u2010Nisour University College Baghdad 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