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Vitamin A and other retinoids also directly inhibit formation of Amyloid fibrils in vivo. These properties of retinoids are relevant to theories of Alzheimer's disease pathogenesis. Retinoids are already used in treatment of acne vulgaris, psoriasis, neuroblastoma and acute promyelocytic leukemia. Clinical studies involving in cognitively impaired older adults with Alzheimer's disease are beginning with a variety of retinoids. These studies need to address safety issues of retinoids in older populations, and hold hope for demonstrating efficacy in translating these basic mechanisms to treatment of a widespread dementing illness.<\/jats:p>","DOI":"10.1002\/biof.196","type":"journal-article","created":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T10:49:13Z","timestamp":1331808553000},"page":"84-89","source":"Crossref","is-referenced-by-count":38,"title":["Retinoids for treatment of Alzheimer's disease"],"prefix":"10.1002","volume":"38","author":[{"given":"Alan J.","family":"Lerner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasia","family":"Gustaw\u2010Rothenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Smyth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Casadesus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,15]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10296"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(92)90002-F"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2460"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389450033346957"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10876"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2004.03.002"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000014450.40853.2B"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03563.x"},{"key":"e_1_2_8_10_2","first-page":"526","article-title":"Effects of marginal vitamin A deficiency and intervention on learning and memory in young rats","volume":"43","author":"Mao C. 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