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Here, by employing the fruit fly <jats:italic>Drosophila melanogaster<\/jats:italic>, we conducted feeding studies supplementing curcumin or, as a control, the iron chelator bathophenanthroline (BPA). First, the absorption and further metabolization of dietary curcuminoids were proved by metabolomics analyses. Next, we found that 0.2% dietary curcumin, similar to BPA, lowered the iron but also the cobalt content, and to a lesser extent affected the manganese and zinc status. Supplementation during larval stages was required and sufficient for both compounds to elicit these alterations in adult animals. However, curcumin\u2010induced retarded larval development was not attributable to the changed trace metal status. In addition, a reduction in the iron content of up to 70% by curcumin or BPA supplementation did not reduce heme\u2010dependent catalase activity and tolerance toward H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> in <jats:italic>D. melanogaster<\/jats:italic>. Moreover, polyamines were not influenced by curcumin treatment and decreased iron levels. This was confirmed for selected organs from 0.2% curcumin\u2010treated mice, except for the spleen. Here, elevated spermidine level and concomitant upregulation of genes involved in polyamine production were associated with a putatively anemia\u2010derived increased spleen mass. Our data underline that the metal\u2010chelating property of curcumin needs to be considered in feeding studies.<\/jats:p>","DOI":"10.1002\/biof.2000","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T04:58:21Z","timestamp":1692680301000},"page":"161-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Reduced iron and cobalt levels in response to curcumin supplementation are not responsible for the prolonged larval development and do not affect the oxidative stress tolerance and polyamine status of <scp><i>D. melanogaster<\/i><\/scp>"],"prefix":"10.1002","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5812-1196","authenticated-orcid":false,"given":"Kai","family":"L\u00fcersen","sequence":"first","affiliation":[{"name":"Division of Food Science Institute of Human Nutrition and Food Science, University of Kiel  Kiel 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