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It has received considerable attention owing to its putative involvement in a wide range of pathophysiological processes such as organ injury, cardiac ischemia\/reperfusion, degenerative disease and its prevalence in plants, invertebrates, yeasts, bacteria, and archaea. To counter ferroptosis, living organisms have evolved a myriad of intrinsic efficient defense systems, such as cyst(e)ine\u2010glutathione\u2010glutathione peroxidase 4 system (cyst(e)ine\u2010GPX4 system), guanosine triphosphate cyclohydrolase 1\/tetrahydrobiopterin (BH\n                    <jats:sub>4<\/jats:sub>\n                    ) system (GCH1\/BH\n                    <jats:sub>4<\/jats:sub>\n                    system), ferroptosis suppressor protein 1\/coenzyme Q\n                    <jats:sub>10<\/jats:sub>\n                    system (FSP1\/CoQ\n                    <jats:sub>10<\/jats:sub>\n                    system), and so forth. Among these, GPX4 serves as the only enzymatic protection system through the reduction of lipid hydroperoxides, while other defense systems ultimately rely on small compounds to scavenge lipid radicals and prevent ferroptotic cell death. In this article, we systematically summarize the chemical biology of lipid radical trapping process by endogenous chemicals, such as coenzyme Q\n                    <jats:sub>10<\/jats:sub>\n                    (CoQ\n                    <jats:sub>10<\/jats:sub>\n                    ), BH\n                    <jats:sub>4<\/jats:sub>\n                    , hydropersulfides, vitamin K, vitamin E, 7\u2010dehydrocholesterol, with the aim of guiding the discovery of novel ferroptosis inhibitors.\n                  <\/jats:p>","DOI":"10.1002\/biof.2015","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T22:01:39Z","timestamp":1701986499000},"page":"266-293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Endogenous chemicals guard health through inhibiting ferroptotic cell death"],"prefix":"10.1002","volume":"50","author":[{"given":"Yuan\u2010Hao","family":"Song","sequence":"first","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals Shandong Normal University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Xu","family":"Lei","sequence":"additional","affiliation":[{"name":"Institute of Process Engineering, Chinese Academy of Sciences  Beijing China"},{"name":"Department of Chemistry University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dou","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Shandong First Medical University  Jinan 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of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals Shandong Normal University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang\u2010Shuai","family":"Meng","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals Shandong Normal University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6822-3866","authenticated-orcid":false,"given":"Xie\u2010Huang","family":"Sheng","sequence":"additional","affiliation":[{"name":"College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals Shandong Normal University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Tissue Engineering Laboratory  Jinan China"},{"name":"Department of Radiology Shandong First Medical University, Shandong Key Laboratory of Rheumatic Disease and Translational Medicine  Jinan 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