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However, the role of LDHA in the pathogenesis of B\u2010cell lymphoma remains unclear. Analysis of data from The Cancer Genome Atlas (TCGA) and Genotype\u2010Tissue Expression (GTEx) databases revealed an elevated LDHA expression in diffuse large B\u2010cell lymphoma (DLBC) tissues compared with normal tissues. Similarly, our results demonstrated a significant increase in LDHA expression in tumor tissues from the patients with B\u2010cell lymphoma compared with those with lymphadenitis. To further elucidate potential roles of LDHA in B\u2010cell lymphoma pathogenesis, we silenced LDHA in the Raji cells (a B\u2010cell lymphoma cell line) using shRNA techniques. Silencing LDHA led to reduced mitochondrial membrane integrity, adenosine triphosphate (ATP) production, glycolytic activity, cell viability and invasion. Notably, LDHA knockdown substantially suppressed in vivo growth of Raji cells and extended survival in mice bearing lymphoma (Raji cells). Moreover, proteomic analysis identified feline sarcoma\u2010related protein (FER) as a differential protein positively associated with LDHA expression. Treatment with E260, a FER inhibitor, significantly reduced the metabolism, proliferation and invasion of Raji cells. In summary, our findings highlight that LDHA plays multiple roles in B\u2010cell lymphoma pathogenesis via FER pathways, establishing LDHA\/FER may as a potential therapeutic target.<\/jats:p>","DOI":"10.1002\/biof.2053","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T05:18:46Z","timestamp":1711084726000},"page":"1024-1038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lactate dehydrogenase A is implicated in the pathogenesis of B\u2010cell lymphoma through regulation of the\n                    <scp>FER<\/scp>\n                    signaling pathway"],"prefix":"10.1002","volume":"50","author":[{"given":"Xiumei","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Hematology The Second Hospital of Shandong University  Jinan China"},{"name":"Department of Hematology Fourth People's Hospital of Jinan City  Jinan 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Hematology The Second Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The Second Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nursing The Second Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Hematology Fourth People's Hospital of Jinan City  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0468-1598","authenticated-orcid":false,"given":"Yang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6260-297X","authenticated-orcid":false,"given":"Chengyun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Hospital of Shandong University  Jinan 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