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Identifying biomarkers that predict prognosis and immune function in patients with BC can enhance our understanding of its pathogenesis and provide valuable guidance for diagnosis and treatment. Our findings indicate that increased ITGB1 expression is associated with higher clinical grade and stage, establishing ITGB1 as an independent prognostic risk factor for BC. Enrichment analysis revealed that the function of ITGB1 in BC was linked to the extracellular matrix. The experimental results showed that ITGB1 knockdown in the BC cell lines 5637 and RT112 reduced their proliferation, migration, and invasion. Furthermore, ITGB1 suppression promotes apoptosis in BC cells by inhibiting the PI3K\u2010AKT pathway. A prognostic risk model incorporating CES1, NTNG1, SETBP1, and AIFM3 was developed based on ITGB1, this model can accurately predict patient prognosis based on immunological status. In conclusion, this study shows that knockdown of ITGB1 can restrain the migratory and invasive capabilities of BC cells and accelerate apoptosis, and this role might be associated with PI3K\u2010AKT, highlighting its potential as a diagnostic marker and therapeutic target for BC.<\/jats:p>","DOI":"10.1002\/biof.2150","type":"journal-article","created":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T04:55:51Z","timestamp":1733547351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Knockdown of integrin \u03b21 inhibits proliferation and promotes apoptosis in bladder cancer cells"],"prefix":"10.1002","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3935-0190","authenticated-orcid":false,"given":"Jin\u2010feng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology First Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang 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