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Initially, they were fed on semi\u2010synthetic equicalories basal diet containing 20 mg Zn (control, group\u2010I), on 40 mg Zn (group\u2010II) and 80 mg Zn\/kg diet (group\u2010III) respectively for 3 months. Thereafter, half of the rats in group\u2010II and III were shifted on Cu and Mg enriched modified poultry egg (ME<jats:sup>\u03a8<\/jats:sup>) mixed diets (groups\u2010IIME and IIIME) while the remaining were continued to feed on their respective diets for another 3 months completing a total of 6 months. Hyperglycemia, hyperinsulinemia, hypercortisolemia, hyperzincemia, hypercupremia and hypermagnesaemia with corresponding increase of lipid droplets in the zona fasciculate of adrenal cortex and reduction in liver glycogen content in rats of groups\u2010II and III were recorded. These changes were linked with a rise in Zn and fall in Cu and Mg in their liver. The addition of ME<jats:sup>\u03a8<\/jats:sup> in their diets led to fall of Zn and rise in liver Cu and Mg, and fall in serum Zn, Cu and Mg resulting in the improvement of glucose disposal, increase in insulin sensitivity, reduction in lipid droplets in zona fasciculate and increase in glycogen content in the liver approaching closer to the control group\u2010I. The data suggest that these ME<jats:sup>\u03a8<\/jats:sup> can serve as non\u2010pharmacological dietary supplement to prevent insulin resistance\/hyperinsulinemia in populations who are at higher risk of diabetes mellitus either due to their genetic predisposition of excessive absorption and retention of Zn or due to higher Zn content in the food chain. \u00a9 2009 International Union of Biochemistry and Molecular Biology, Inc.<\/jats:p>","DOI":"10.1002\/biof.51","type":"journal-article","created":{"date-parts":[[2009,6,29]],"date-time":"2009-06-29T13:34:13Z","timestamp":1246282453000},"page":"389-398","source":"Crossref","is-referenced-by-count":4,"title":["Modulation of Zn\u2010induced hyperinsulinemia\/insulin resistance in Wistar rat fed modified poultry egg<sup>\u03a8<\/sup>"],"prefix":"10.1002","volume":"35","author":[{"given":"Satish Kumar","family":"Taneja","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reshu","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,6,29]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"1","article-title":"Review article\u2014Zinc in endocrinology","volume":"16","author":"Kaji M.","year":"2001","journal-title":"Int. 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