{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:00:54Z","timestamp":1761217254322},"reference-count":24,"publisher":"Wiley","issue":"2-4","license":[{"start":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T00:00:00Z","timestamp":1229385600000},"content-version":"vor","delay-in-days":3637,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We used in vivo phosphorus magnetic resonance spectroscopy (<jats:sup>31<\/jats:sup>P\u2010MRS) to study the effect of CoQ<jats:sub>10<\/jats:sub> on the efficiency of brain and skeletal muscle mitochondrial respiration in ten patients with mitochondrial cytopathies. Before CoQ, brain [PCr] was remarkably lower in patients than in controls, while [Pi] and [ADP] were higher. Brain cytosolic free [Mg<jats:sup>2+<\/jats:sup>] and \u0394 G of ATP hydrolysis were also abnormal in all patients. MRS also revealed abnormal mitochondrial function in the skeletal muscles of all patients, as shown by a decreased rate of PCr recovery from exercise. After six\u2010months of treatment with CoQ (150 mg\/day), all brain MRS\u2010measurable variables as well as the rate of muscle mitochondrial respiration were remarkably improved in all patients. These in vivo findings show that treatment with CoQ in patients with mitochondrial cytopathies improves mitochondrial respiration in both brain and skeletal muscles, and are consistent with Lenaz's view that increased CoQ concentration in the mitochondrial membrane increases the efficiency of oxidative phosphorylation independently of enzyme deficit.<\/jats:p>","DOI":"10.1002\/biof.5520090221","type":"journal-article","created":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T00:44:41Z","timestamp":1229647481000},"page":"253-260","source":"Crossref","is-referenced-by-count":34,"title":["Improved brain and muscle mitochondrial respiration with CoQ. An <i>in vivo<\/i> study by <sup>31<\/sup>P\u2010MR spectroscopy in patients with mitochondrial cytopathies"],"prefix":"10.1002","volume":"9","author":[{"given":"Bruno","family":"Barbiroli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Iotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Lodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1993.61"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.7.1364"},{"key":"e_1_2_1_4_2","first-page":"741","article-title":"Coenzyme Q10 improves respiration in patients with mitochondrial cytopathies. An in vivo study on brain and skeletal muscle by phosphorus magnetic resonance spectroscopy","volume":"43","author":"Barbiroli B.","year":"1997","journal-title":"Cell. Molec. Biol."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006839403270"},{"key":"e_1_2_1_6_2","unstructured":"B.Barbiroli S.Iotti P.Cortelli P.Martinelli R.Lodi V.CarelliandP.Montagna Low brain intracellular free magnesium in mitochondrial cytopathies J. Cerebr. Blood Flow Metab. (in press)."},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.6.1203"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.6.2528"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/clinchem\/35.3.392","article-title":"Rapid reliable in vivo assay of human phosphate metabolism by nuclear magnetic resonance","volume":"35","author":"Bottomley P. A.","year":"1989","journal-title":"Clin. 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