{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T14:06:56Z","timestamp":1768831616736,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"2-4","license":[{"start":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T00:00:00Z","timestamp":1229385600000},"content-version":"vor","delay-in-days":3637,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Parkinson's disease (PD) is a degenerative neurological disorder. Recent studies have demonstrated reduced activity of complex I of the electron transport chain in brain and platelets from patients with PD. Platelet mitochondria from parkinsonian patients were found to have lower levels of coenzyme Q<jats:sub>10<\/jats:sub> (CoQ<jats:sub>10<\/jats:sub>) than mitochondria from age\/sex\u2010matched controls. There was a strong correlation between the levels of CoQ<jats:sub>10<\/jats:sub> and the activities of complexes I and II\/III. Oral CoQ<jats:sub>10<\/jats:sub> was found to protect the nigrostriatal dopaminergic system in one\u2010year\u2010old mice treated with MPTP, a toxin injurious to the nigrostriatal dopaminergic system. We further found that oral CoQ<jats:sub>10<\/jats:sub> was well absorbed in parkinsonian patients and caused a trend toward increased complex I activity. These data suggest that CoQ<jats:sub>10<\/jats:sub> may play a role in cellular dysfunction found in PD and may be a potential protective agent for parkinsonian patients.<\/jats:p>","DOI":"10.1002\/biof.5520090223","type":"journal-article","created":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T00:44:38Z","timestamp":1229647478000},"page":"267-272","source":"Crossref","is-referenced-by-count":56,"title":["A possible role of coenzyme Q<sub>10<\/sub> in the etiology and treatment of Parkinson's disease"],"prefix":"10.1002","volume":"9","author":[{"given":"Clifford W.","family":"Shults","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard H.","family":"Haas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Flint","family":"Beal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.25.1.1"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01192-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/116.6.1451"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1970.tb09904.x"},{"key":"e_1_2_1_6_2","first-page":"1732","volume-title":"Harrison's Principles of Internal Medicine","author":"Bunn H. 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