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Mechanisms underlying the effects of copper deficiency on thrombin\u2010 induced signals that elicit dense granule secretion involve suppression of protein kinase C activity and impairment of Ca<jats:sup>2+<\/jats:sup> release from intracellular stores. Copper deficiency also reduces the cellular GTP content of platelets. This may limit receptor effector coupling through GTP\u2010dependent regulatory proteins leading to protein kinase C activation and the release of Ca<jats:sup>2+<\/jats:sup> from intracellular stores. The reduction in GTP content during copper deficiency results from its utilization to maintain cellular ATP levels in response to severely inhibited cytochrome c oxidase activity in platelet mitochondria. Thus, the role of copper in maintaining normal signal transduction may be indirectly related to its biological function in mitochondria.<\/jats:p>","DOI":"10.1002\/biof.5520100106","type":"journal-article","created":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T00:22:31Z","timestamp":1229646151000},"page":"53-59","source":"Crossref","is-referenced-by-count":5,"title":["Copper and signal transduction: Platelets as a model to determine the role of copper in stimulus\u2010response coupling"],"prefix":"10.1002","volume":"10","author":[{"given":"W.","family":"Thomas Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"301","volume-title":"Biochemical Basis of the Clinical Effects of Copper Deficiency","author":"O'Dell B. 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