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The dose\u2010response curves, reversibility, and organ\u2010and species specificity are distinct. Genotoxic carcinogens are mutagenic, form DNA adducts, induce DNA repair, and form hydroxy radicals and inappropriate peroxidation reactions that antioxidants such as those in vegetables, fruits, and tea can decrease. In contrast, promoters do not form DNA adducts, but raise cell duplication rates, among other attributes. In the USA, about 35% about 55% decreased by avoiding the formation of carcinogens, reducing their metabolic activation, or increasing their detoxification. Excessive dietary salt, and heterocyclic arylamines formed in cooking of meats or fish, and high intake of 40% vegetables, fruits, tea, soy products, and fibers are protective. We review nutritional factors involved in cancer and chronic disease causation and prevention.<\/jats:p>","DOI":"10.1002\/biof.5520120112","type":"journal-article","created":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T00:52:01Z","timestamp":1229647921000},"page":"73-81","source":"Crossref","is-referenced-by-count":14,"title":["Prevention of cancer and other chronic diseases worldwide based on sound mechanisms"],"prefix":"10.1002","volume":"12","author":[{"given":"John H.","family":"Weisburger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/50.5.1137"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(98)00269-0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx9500585"},{"key":"e_1_2_1_5_2","first-page":"208","article-title":"Hepatocellular carcinoma not related to hepatitis B virus infection among Alaska natives","volume":"58","author":"Chung Y. 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