{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T08:27:13Z","timestamp":1769588833257,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"1-4","license":[{"start":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T00:00:00Z","timestamp":1229385600000},"content-version":"vor","delay-in-days":2906,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the present work was to clarify whether the activities of selenoenzymes can serve as markers for different tumors or goiters, as classified by histological criteria. The following parameters were determined: 1) selenium content of plasma (Se), 2) activities of the selenoenzymes: plasma glutathione peroxidase (plGSHPx), cytosolic glutathione peroxidase (cGSHPx), type I and type II iodothyronine deiodinases (ID\u2010I, ID\u2010II), thioredoxin reductase (THRR) in human thyroid tissues. The material came from follicular neoplasm, papillary carcinoma, struma nodosa, struma lymphomatosis Hashimoto, other thyroid surgery specimens, and normal tissues. There was no difference in Se nor in plGSHPx between patients and healthy volunteers. No significant differences were found for any parameter in thyroid carcinoma versus normal or goitrous thyroid tissue. In the whole group of thyroid surgery specimens the statistically significant correlations were found between ID\u2010I and ID\u2010II and between THRR and selenoperoxidases. Principal components analysis confirmed the above correlation and moreover revealed correlation between Se and plGSHPx, but did not detect any clear distinction between patients with the different diagnoses.<\/jats:p>","DOI":"10.1002\/biof.5520140128","type":"journal-article","created":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T01:02:01Z","timestamp":1229648521000},"page":"223-227","source":"Crossref","is-referenced-by-count":15,"title":["Selenoproteins in human thyroid tissues"],"prefix":"10.1002","volume":"14","author":[{"given":"Pawe\u0142","family":"Zagrodzki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fergus","family":"Nicol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Arthur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"S\u0142owiaczek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02783990"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)80905-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"244S","DOI":"10.1093\/ajcn\/57.2.244S","article-title":"Selenium and the thyroid: how the relationship was established","volume":"57","author":"Corvilain B.","year":"1993","journal-title":"Am J Clin Nutr Supl"},{"key":"e_1_2_1_5_2","first-page":"75","volume-title":"The Thyroid and Iodine","author":"Feldt\u2010Rasmussen U.","year":"1996"},{"key":"e_1_2_1_6_2","series-title":"Program and Abstract Book","first-page":"132","volume-title":"The Sixth International Symposium on Selenium in Biology and Medicine","author":"K\u00f6hrle J.","year":"1996"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(99)80105-9"},{"key":"e_1_2_1_8_2","first-page":"323","article-title":"Diagnosis and treatment of differentiated thyroid carcinomas; how far we are from OWN and international standards","volume":"49","author":"Osikowska\u2010Loksztejn M.","year":"1998","journal-title":"Polish J Endocrinol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(98)90127-8"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.2307\/3454297"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/an9952000817"}],"container-title":["BioFactors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbiof.5520140128","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.5520140128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T15:54:19Z","timestamp":1693410859000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/biof.5520140128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":10,"journal-issue":{"issue":"1-4","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["10.1002\/biof.5520140128"],"URL":"https:\/\/doi.org\/10.1002\/biof.5520140128","archive":["Portico"],"relation":{},"ISSN":["0951-6433","1872-8081"],"issn-type":[{"value":"0951-6433","type":"print"},{"value":"1872-8081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}