{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:06:18Z","timestamp":1790049978527,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T00:00:00Z","timestamp":1229385600000},"content-version":"vor","delay-in-days":2176,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the present study, we investigated the differential role of the mitochondrial glutathione status and induction of heat shock proteins (HSPs) 25\/70 in protecting against carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) hepatotoxicity in schisandrin B (Sch B)\u2010pretreated mice. The time\u2010course of Sch B\u2010induced changes in these hepatic parameters were examined. Dimethyl diphenyl bicarboxylate (DDB), a non\u2010hepatoprotective analog of Sch B, was studied for comparison. Sch B treatment (2 mmol\/kg) produced maximal enhancement in hepatic mitochondrial glutathione status as well as increases in hepatic HSP 25\/70 levels at 24 h post\u2010dosing. The stimulatory effect of Sch B then gradually subsided, but the activities of hepatic mitochondrial glutathione reductase (GR) and glutathione S\u2010transferases (GST) as well as the level of HSP 25 remained relatively high even at 72 h post\u2010dosing. CCl<jats:sub>4<\/jats:sub>challenge caused significant impairment in mitochondrial glutathione status and a decrease in HSP 70 level, but the HSP 25 level was significantly elevated. While the extent of hepatoprotection afforded by Sch B pretreatment against CCl<jats:sub>4<\/jats:sub>was found to inversely correlate with the time elapsed after the dosing, the protective effect was associated with the ability of Sch B to maintain the mitochondrial glutathione status and\/or induce further production of HSP 25 in CCl<jats:sub>4<\/jats:sub>\u2010intoxicated condition. On the other hand, DDB treatment (2 mmol\/kg), which did not increase mitochondrial GSH level and GST activity or induce further production of HSP 25 after CCl<jats:sub>4<\/jats:sub>challenge, could not protect against CCl<jats:sub>4<\/jats:sub>toxicity. The results suggest that the enhancement of mitochondrial glutathione status and induction of HSP 25\/70 may contribute independently to the hepatoprotection afforded by Sch B pretreatment.<\/jats:p>","DOI":"10.1002\/biof.5520190105","type":"journal-article","created":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T01:22:35Z","timestamp":1229649755000},"page":"33-42","source":"Crossref","is-referenced-by-count":26,"title":["Hepatoprotective action of schisandrin B against carbon tetrachloride toxicity was mediated by both enhancement of mitochondrial glutathione status and induction of heat shock proteins in mice"],"prefix":"10.1002","volume":"19","author":[{"given":"Man Ho","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po Yee","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kam Ming","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"75","volume-title":"A clinical guide to Chinese herbs and formulae","author":"Chen S.Y.","year":"1993"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/332805a0"},{"key":"e_1_2_1_4_2","unstructured":"P.Y.ChiuandK.M.Ko Time dependent enhancement in mitochondrial glutathione status and ATP generation capacity by schisandrin B treatment decreases the susceptibility of rat hearts to ischemia\u2010reperfusion injury Biofactors(in press)."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1997.0623"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/332800a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0026-895X(25)10539-7","article-title":"Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor\u2010kappa B: studies with isolated mitochondria and rat hepatocytes","volume":"48","author":"Garcia\u2010Ruiz C.","year":"1995","journal-title":"Mol. 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