{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:07:00Z","timestamp":1783487220985,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T00:00:00Z","timestamp":1229385600000},"content-version":"vor","delay-in-days":2176,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We recently conducted a prospective, placebo\u2010controlled clinical study, where we could demonstrate, that a substitution of 200 \u03bcg sodium selenite for three months in patients with autoimmune thyroiditis reduced thyroid peroxidase antibody (TPO\u2010Ab) concentrations significantly. Forty\u2010seven patients from the initially 70 patients agreed to participate in a follow\u2010up cross\u2010over study for further six months. One group (<jats:italic>n<\/jats:italic> = 13), which initially received selenium continued to take 200 \u03bcg sodium selenite (Se\u2010Se), one group stopped taking selenium (Se\u20100) ( <jats:italic>n<\/jats:italic> = 9), another group which received placebo started to take 200 \u03bcg selenium (<jats:italic>n<\/jats:italic> = 14) (Plac\u2010Se) and the last group was without selenium substitution (Plac\u20100) (<jats:italic>n<\/jats:italic> = 11). TPO\u2010Ab concentrations were measured at beginning and the end of the study. In the Se\u2010Se group, the TPO\u2010Ab concentrations further significantly <jats:italic>p<\/jats:italic> = 0.004) decreased from 625 \u00b1 470 U\/ml to 354 \u00b1 321 U\/ml, in the Se\u20100 group the TPO\u2010Ab concentrations increased significantly <jats:italic>p<\/jats:italic> = 0.017) from 450 \u00b1 335 to 708 \u00b1 313 U\/ml. In the placebo group, the TPO\u2010Ab concentrations in those patients who were followed without selenium substitution were unchanged (1351 \u00b1 940 vs. 1724 \u00b1 1112 U\/ml, <jats:italic>p<\/jats:italic> = 0.555). In contrast, the patients who received 200 \u03bcg sodium selenite after placebo, the TPO\u2010Ab concentrations decreased significantly (<jats:italic>p<\/jats:italic> = 0.029) from 1182 \u00b1 723 to 643 \u00b1 477 U\/ml.<\/jats:p>","DOI":"10.1002\/biof.5520190309","type":"journal-article","created":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T01:19:11Z","timestamp":1229649551000},"page":"165-170","source":"Crossref","is-referenced-by-count":66,"title":["Selenium in the treatment of autoimmune thyroiditis"],"prefix":"10.1002","volume":"19","author":[{"given":"Roland","family":"G\u00e4rtner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara C. 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