{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T14:45:42Z","timestamp":1758120342611},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T00:00:00Z","timestamp":1229644800000},"content-version":"vor","delay-in-days":1448,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>: to describe the effect of CoQ10 (added to either a fibrate, or PUFA or association of both) in patients affected by massive hypertriglyceridemia (MHTG) resistant to fibrates and PUFA.<\/jats:p><jats:p><jats:italic>Design:<\/jats:italic> Open, sequential, comparative intervention study. Setting: Specialised centres for dyslipidemia management.<\/jats:p><jats:p><jats:italic>Subjects<\/jats:italic>: 15 subjects (mean age: 45.1 \u00b1 12.5 years) affected by MHTG and hyporesponsive to either fibrates, or PUFA, or fibrates\u2010PUFA association, and 15 age\u2010matched subjects regularly responders to PUFA and fenofibrate treatment.<\/jats:p><jats:p><jats:italic>Interventions<\/jats:italic>: Treatment for periods of 6 weeks each with the following consecutive treatments: CoQ10 150 mg\/day, PUFA 3000 mg\/day, fenofibrate 200 mg\/day, PUFA 3000 mg\/day + fenofibrate 200 mg\/day, PUFA 3000 mg\/day + CoQ10 150 mg\/day, fenofibrate 200 mg\/day + CoQ10 150 mg\/day, and finally, fenofibrate 200 mg\/day + PUFA 3000 mg\/day + CoQ10 150 mg\/day.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: CoQ10 supplementation improved, in the control group, systolic and diastolic blood pressure, creatinine and Lp(a) plasma levels, both during fenofibrate and\/or PUFA treatment. In MHTG group, CoQ10 supplementation significantly improved TG, TC, Lp(a), uric acid and blood pressure during fenofibrate treatment, but only Lp(a) and blood pressure during PUFA treatment. Fenofibrate appeared to have better effect on hsCRP and \u03b3\u2010GT plasma levels than PUFA. No significant change was observed in any group and under any treatment in regards to homocysteinemia, PAI\u20101, or t\u2010PA.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: Even though the mechanism of action through which the effects were obtained is yet to be elucidated, adding CoQ10 to fenofibrate could improve the drug's efficacy in MHTG patients not responding to fenofibrate alone.<\/jats:p>","DOI":"10.1002\/biof.5520230102","type":"journal-article","created":{"date-parts":[[2008,12,25]],"date-time":"2008-12-25T09:37:13Z","timestamp":1230197833000},"page":"7-14","source":"Crossref","is-referenced-by-count":12,"title":["Treatment of massive hypertriglyceridemia resistant to PUFA and fibrates: A possible role for the coenzyme Q10?"],"prefix":"10.1002","volume":"23","author":[{"given":"A.F.G.","family":"Cicero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Derosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Miconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Laghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Nascetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gaddi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,19]]},"reference":[{"issue":"2","key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/ajcn\/71.2.472","article-title":"Cholesterol\u2010lowering effects of psyIlium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta\u2010analysis of 8 controlled trials","volume":"71","author":"Anderson J.W.","year":"2000","journal-title":"Am. 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