{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:57:52Z","timestamp":1785463072784,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"1-4","license":[{"start":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T00:00:00Z","timestamp":1229644800000},"content-version":"vor","delay-in-days":1448,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oxidative stress is considered a key factor in HELLP syndrome, a severe complication of preeclampsia in pregnancy. In the present study we analysed the content of Coenzyme Q<jats:sub>10<\/jats:sub> (CoQ<jats:sub>10<\/jats:sub>), a fundamental component of the mitochondrial respiratory chain and recognized lipophilic antioxidant, in placentas from women affected by HELLP syndrome and compared them with the relative controls.<\/jats:p><jats:p>Twenty\u2010eight patients with HELLP syndrome and twenty\u2010eight age\u2010matched healthy pregnant controls were enrolled. Two aliquots of placental tissue were taken immediately after delivery and placed into liquid nitrogen. Thawed samples were homogenised by Ultra\u2010Turrax; total protein and CoQ<jats:sub>10<\/jats:sub> concentration were thereafter analysed. CoQ<jats:sub>10<\/jats:sub> concentration was 0.162 \u00b1 0.07\u03bcg\/mg protein in HELLP syndrome versus 0.87 \u00b1 0.003\u03bcg\/mg protein in controls, the difference being highly significant. A positive correlation, within the placentas from HELLP, was found between the weight of the new\u2010born and CoQ<jats:sub>10<\/jats:sub> \/protein ratio. A significant positive correlation was also present between CoQ<jats:sub>10<\/jats:sub>\/protein ratio and Apgar at 1st and 5th minute as well as between CoQ<jats:sub>10<\/jats:sub>\/protein ratio and the median cerebral artery pulsatility index. The increase in placental CoQ<jats:sub>10<\/jats:sub> in this syndrome might derive from a compensatory mechanism in a situation of increased oxidative stress.<\/jats:p>","DOI":"10.1002\/biof.5520250118","type":"journal-article","created":{"date-parts":[[2008,12,25]],"date-time":"2008-12-25T09:28:48Z","timestamp":1230197328000},"page":"159-163","source":"Crossref","is-referenced-by-count":6,"title":["Placental CoQ<sub>10<\/sub> levels in HELLP syndrome"],"prefix":"10.1002","volume":"25","author":[{"given":"Stefano R.","family":"Giannubilo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"Tranquilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Santolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Prinicipi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Mancinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Paolo","family":"Littarru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0910711"},{"key":"e_1_2_1_3_2","first-page":"668","article-title":"Mechanism of action of coenzyme Q10 in essential hypertension","volume":"51","author":"Digiesi V.","year":"1992","journal-title":"Curr Therapeutic Res"},{"key":"e_1_2_1_4_2","first-page":"841","article-title":"Effect of coenzyme Q10 on essential arterial hypertension","volume":"47","author":"Digiesi V.","year":"1990","journal-title":"Curr Therapeutic Res"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0098-2997(94)90036-1"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0095-5108(18)30490-1","article-title":"Pathophysiology of pre\u2010eclampsia","volume":"4","author":"Friedman S. 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