{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:22:33Z","timestamp":1773292953829,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"1-4","license":[{"start":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T00:00:00Z","timestamp":1229644800000},"content-version":"vor","delay-in-days":1448,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Coenzyme Q10 (CoQ<jats:sub>10<\/jats:sub>) levels in human saliva were measured by HPLC with a highly sensitive electrochemical detector (ECD) and a special concentration column. This HPLC system showed satisfactory analytical results within the standard range of 0.78\u201350 ng\/ml. We also found a significant correlation between CoQ<jats:sub>10<\/jats:sub> levels in plasma and in saliva from parotid glands, while this correlation was lacking between plasma CoQ<jats:sub>10<\/jats:sub> and CoQ<jats:sub>10<\/jats:sub> in whole saliva. Unlike in plasma, there are some fluctuations of saliva CoQ<jats:sub>10<\/jats:sub> levels throughout the day. A good correlation was obtained by colleting parotid gland saliva at times between meals. The mean saliva CoQ<jats:sub>10<\/jats:sub> level for 55 healthy volunteers was 17.0 ng\/ml (S.D. 6.8 ng\/ml); approximately one fiftieth of that in plasma.<\/jats:p><jats:p>Regarding the influence of oral supplementation, CoQ<jats:sub>10<\/jats:sub> was analyzed in plasma and parotid gland saliva from 20 healthy volunteers supplemented daily with 100 mg of CoQ<jats:sub>10<\/jats:sub> for the first week and 200 mg for the second. The plasma CoQ<jats:sub>10<\/jats:sub> levels of all volunteers increased to different extents in accordance with the CoQ<jats:sub>10<\/jats:sub> daily intake and the corresponding change in saliva showed almost the same trend.<\/jats:p>","DOI":"10.1002\/biof.5520250125","type":"journal-article","created":{"date-parts":[[2008,12,25]],"date-time":"2008-12-25T09:28:48Z","timestamp":1230197328000},"page":"205-211","source":"Crossref","is-referenced-by-count":13,"title":["Estimation of plasma and saliva levels of coenzyme Q<sub>10<\/sub> and influence of oral supplementation"],"prefix":"10.1002","volume":"25","author":[{"given":"K.","family":"Sekine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Ota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Uetake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Shimadzu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520180221"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/abio.2002.5653"},{"key":"e_1_2_1_4_2","unstructured":"Japan Applied Patent 2002\u2013351677 PCT\/JP2003\/015478."},{"key":"e_1_2_1_5_2","unstructured":"Japan Applied Patent 2004\u2013059834 PCT\/JP2005\/003651."},{"key":"e_1_2_1_6_2","first-page":"67","article-title":"Estimation of plasma levels of Coenzyme Q10 and relationship to oral dosage","volume":"3","author":"Kishi T.","year":"1981","journal-title":"Elsevier\/North\u2010Holland Biomedical Press"}],"container-title":["BioFactors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbiof.5520250125","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.5520250125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T06:40:15Z","timestamp":1693377615000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/biof.5520250125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":5,"journal-issue":{"issue":"1-4","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1002\/biof.5520250125"],"URL":"https:\/\/doi.org\/10.1002\/biof.5520250125","archive":["Portico"],"relation":{},"ISSN":["0951-6433","1872-8081"],"issn-type":[{"value":"0951-6433","type":"print"},{"value":"1872-8081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}