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Male Mongolian gerbils were divided into 4 groups (normal group without <jats:italic>H. pylori<\/jats:italic> infection, vitamin E\u2010deficient, \u2010sufficient and \u2010supplemented groups with <jats:italic>H. pylori<\/jats:italic> infection). Following oral inoculation with <jats:italic>H. pylori<\/jats:italic> (ATCC43504 2 \u00d7 10<jats:sup>8<\/jats:sup> CFU), animals were fed diets \u03b1\u2010tocopherol 2 mg\/100 g diet in the normal and vitamin E\u2010sufficient groups and \u03b1\u2010tocopherol 0.1 mg\/100 g and 50 mg\/100 g in the vitamin E\u2010deficient and \u2010supplemented groups, respectively, for 24 weeks. Chronic gastritis was detected in all gerbils inoculated <jats:italic>H. pylori<\/jats:italic>. Gastric ulcer was detected in 2 of 7 gerbils only in the vitamin E\u2010deficient group. In the vitamin E\u2010deficient group, myeloperoxidase activity and mouse keratinocyte derived chemokine (KC) in gastric mucosa was significantly higher than in the vitamin E supplemented group. Subsequently, in an <jats:italic>in vitro<\/jats:italic> study expression of CD11b\/CD18 on neutrophils was enhanced by <jats:italic>H. pylori<\/jats:italic> water extract. This effect was suppressed in a dose dependent manner by the addition of \u03b1\u2010tocopherol. These results suggest that vitamin E has a protective effect on gastric mucosal injury induced by <jats:italic>H. pylori<\/jats:italic> infection in gerbils, through the inhibition of accumulation of activated neutrophils.<\/jats:p>","DOI":"10.1002\/biof.5520280102","type":"journal-article","created":{"date-parts":[[2008,12,25]],"date-time":"2008-12-25T09:43:03Z","timestamp":1230198183000},"page":"9-19","source":"Crossref","is-referenced-by-count":19,"title":["Influence of vitamin E on gastric mucosal injury induced by <i>Helicobacter pylori<\/i> infection"],"prefix":"10.1002","volume":"28","author":[{"given":"Naohito","family":"Sugimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norimasa","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunari","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Naito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Okanoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikazu","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.21.183"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02088233"},{"key":"e_1_2_1_4_2","first-page":"543","article-title":"Decrease 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