{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:05:09Z","timestamp":1790895909064,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"1-4","license":[{"start":{"date-parts":[[2009,4,7]],"date-time":"2009-04-07T00:00:00Z","timestamp":1239062400000},"content-version":"vor","delay-in-days":462,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinical studies demonstrated the efficacy of Coenzyme Q<jats:sub>10<\/jats:sub> (CoQ<jats:sub>10<\/jats:sub>) as an adjuvant therapeutic in cardiovascular diseases, mitochondrial myopathies and neurodegenerative diseases. More recently, expression profiling revealed that Coenzyme Q<jats:sub>10<\/jats:sub> (CoQ<jats:sub>10<\/jats:sub>) influences the expression of several hundred genes. To unravel the functional connections of these genes, we performed a text mining approach using the Genomatix BiblioSphere. We identified signalling pathways of G\u2010protein coupled receptors, JAK\/STAT, and Integrin which contain a number of CoQ<jats:sub>10<\/jats:sub> sensitive genes. Further analysis suggested that IL5, thrombin, vitronectin, vitronectin receptor, and C\u2010reactive protein are regulated by CoQ<jats:sub>10<\/jats:sub> via the transcription factor NF\u03baB1. To test this hypothesis, we studied the effect of CoQ<jats:sub>10<\/jats:sub> on the NF\u03baB1\u2010dependent pro\u2010inflammatory cytokine TNF\u2010\u03b1. As a model, we utilized the murine macrophage cell lines RAW264.7 transfected with human apolipoprotein E3 (apoE3, control) or pro\u2010inflammatory apoE4. In the presence of 2.5 \u03bcM or 75 \u03bcM CoQ<jats:sub>10<\/jats:sub> the LPS\u2010induced TNF\u2010\u03b1 response was significantly reduced to 73.3\u00b12.8% and 74.7\u00b18.9% in apoE3 or apoE4 cells, respectively. Therefore, the in silico analysis as well as the cell culture experiments suggested that CoQ<jats:sub>10<\/jats:sub> exerts anti\u2010inflammatory properties via NF\u03baB1\u2010dependent gene expression.<\/jats:p>","DOI":"10.1002\/biof.5520320121","type":"journal-article","created":{"date-parts":[[2009,4,7]],"date-time":"2009-04-07T15:01:52Z","timestamp":1239116512000},"page":"179-183","source":"Crossref","is-referenced-by-count":237,"title":["Functions of coenzyme Q<sub>10<\/sub> in inflammation and gene expression"],"prefix":"10.1002","volume":"32","author":[{"given":"Constance","family":"Schmelzer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inka","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Rimbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Niklowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Menke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"D\u00f6ring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)00171-U"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-006-1390-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.11.017"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","unstructured":"L.Jofre\u2010Monseny S.de Pascual\u2010Teresa E.Plonka P.Huebbe C.Boesch\u2010Saadatmandi A. M.MinihaneandG.Rimbach Differential effects of apolipoprotein E3 and E4 on markers of oxidative status in macrophages Br J Nutr (2007) 1\u20138.","DOI":"10.1017\/S0007114507669219"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.03.150"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.52.3.465"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mco.0000171123.60665.16"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0996-55"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.12.1916089"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.8.2.8119492"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/15216540701545991"},{"key":"e_1_2_1_13_2","unstructured":"C.Schmelzer G.Lorenz I.Lindner G.Rimbach P.Niklowitz T.MenkeandF.Doring Effects of coenzyme Q10on TNF\u2010\u03b1 secretion in human and murine monocytic cell lines BioFactors (in press)."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.1.35"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.11.5573-5578.1999"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1128\/iai.63.4.1529-1534.1995","article-title":"Lipopolysaccharide\u2010inducible and salicylate\u2010sensitive nuclear factor(s) on human tumor necrosis factor alpha promoter","volume":"63","author":"Takashiba S.","year":"1995","journal-title":"Infect Immun"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2007.01.019"}],"container-title":["BioFactors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbiof.5520320121","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.5520320121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T16:44:22Z","timestamp":1693500262000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/biof.5520320121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":16,"journal-issue":{"issue":"1-4","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1002\/biof.5520320121"],"URL":"https:\/\/doi.org\/10.1002\/biof.5520320121","archive":["Portico"],"relation":{},"ISSN":["0951-6433","1872-8081"],"issn-type":[{"value":"0951-6433","type":"print"},{"value":"1872-8081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}