{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:25:52Z","timestamp":1791231952440,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,8,19]],"date-time":"2009-08-19T00:00:00Z","timestamp":1250640000000},"content-version":"vor","delay-in-days":596,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Insulin like growth factor\u20101 (IGF\u20101) is ubiquitously expressed growth factor that has profound effects on the growth and differentiation of many cell types and tissues, including cells of the central nervous system (CNS). IGF\u20101 is produced by a wide variety of cells and is found in many biological fluids including cerebrospinal fluid (CSF). IGF\u20101 plays important role during CNS development and repair. IGF\u20101 has broad range neuroprotective effects and is a therapeutic candidate for Huntington's disease (HD). IGF\u20101 protects striatal neurons from the toxicity of mutated Huntington <jats:italic>in vitro<\/jats:italic> and improves neuronal survival <jats:italic>in vivo<\/jats:italic> in a phenotypic model of HD. Alzheimer's disease (AD) is an age\u2010dependent dementia characterized by progressive loss of cognitive functions and by characteristic pathological changes in the brain: the formation of aggregates extracellularly by \u00df\u2010amyloid (AB) peptide and intracellularly by tau proteins. Since cerebrospinal fluid (CSF) is in contact with the extracellular space of the brain, biochemical brain modifications could be reflected in the CSF. IGFs in circulation and other physiological fluids are associated with a group of high\u2010affinity binding proteins insulin like growth factor binding proteins (IGFBPs) that specifically bind and modulate their bioactivity at the cellular level. The aim of this study was to determine the level of CSF and serum IGF\u20101 and IGFBPs concentrations in the patients with AD. CSF was obtained by lumbar puncture. The presence of IGF\u20101 and IGFBPs in the CSF and serum samples was confirmed by Western blot using anti\u2010IGF\u20101 and IGFBPs antibodies. Using enzyme linked immunosorbent assay (ELISA), it was shown that the concentration of CSF and serum IGF\u20101 and IGFBPs in the patients with AD is higher than in normal control. The data from this study indicate that IGF\u20101 is a constant component of human CSF. It is also concluded that high levels of CSF IGF\u20101 may be partly related to AD pathophysiology.<\/jats:p>","DOI":"10.1002\/biof.5520330202","type":"journal-article","created":{"date-parts":[[2009,8,19]],"date-time":"2009-08-19T14:46:29Z","timestamp":1250693189000},"page":"99-106","source":"Crossref","is-referenced-by-count":59,"title":["Insulin like growth factor\u20101 and insulin like growth factor binding proteins in the cerebrospinal fluid and serum from patients with Alzheimer's 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