{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:03:33Z","timestamp":1761059013061},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,11,3]],"date-time":"2009-11-03T00:00:00Z","timestamp":1257206400000},"content-version":"vor","delay-in-days":672,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many recent studies have suggested that low\u2010density lipoprotein (LDL) oxidation, endothelial dysfunction, and inflammation are involved in the pathogenesis of atherosclerosis. Herbal regimens in the treatment of blood stasis, a counterpart of atherosclerosis, commonly use medicinal plants of leguminosae and labiatae. We have developed disease\u2010oriented screening methods to search for bioactive components, particularly isoflavones in leguminosae and polyphenols in labiatae from Chinese herbal medicines. Many bioactive components and active fractions capable of inhibiting a. Cu(II)\u2010induced LDL oxidation, b. oxidized LDL\u2010induced endothelial damage, c. uptake of oxidized LDL by macrophages (J774A.1), and d. expression of cell adhesion molecules (CAMs) have been identified. A polyphenol, namely salvianolic acid B from <jats:italic>Salvia miltiorrhiza<\/jats:italic> was identified to be a potent antioxidant, endothelial\u2010protecting agent, and an inhibitor to suppress the expression of ICAM and VCAM. This review also briefly describes the strategy for developing herbal medicines as anti\u2010atherosclerotic agents.<\/jats:p>","DOI":"10.1002\/biof.5520340206","type":"journal-article","created":{"date-parts":[[2009,11,3]],"date-time":"2009-11-03T15:02:43Z","timestamp":1257260563000},"page":"147-157","source":"Crossref","is-referenced-by-count":31,"title":["In search of antioxidants and anti\u2010atherosclerotic agents from herbal medicines"],"prefix":"10.1002","volume":"34","author":[{"given":"Ming\u2010Shi","family":"Shiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing\u2010Jing","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Ping","family":"Jen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao\u2010Wen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye\u2010Jer","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuh\u2010Lien","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,11,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.1176"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.17.10123"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199708073370607"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(99)00101-1"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/66.2.267"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00238-0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1992.tb16848.x"},{"key":"e_1_2_1_9_2","first-page":"175","article-title":"A salvianolic acid B\u2010rich fraction of Salvia miltiorrhiza induces neointimal cell apoptosis in rabbit angioplasty model","volume":"16","author":"Hung H.\u2010H.","year":"2001","journal-title":"Histol Histopathol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.9.1222"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.537878"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(94)00253-U"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.13.1733"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.14.4.605"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1016\/S0022-2275(20)32089-7","article-title":"Oxidants and antioxidants in atherosclerosis: an appraisal","volume":"40","author":"Parthasarathy S.","year":"1999","journal-title":"J Lipid Res"},{"key":"e_1_2_1_16_2","unstructured":"K.J. 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