{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T16:39:05Z","timestamp":1720715945897},"reference-count":4,"publisher":"Wiley","issue":"1-4","license":[{"start":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T00:00:00Z","timestamp":1229385600000},"content-version":"vor","delay-in-days":1811,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Konjac glucomannan (GM) is a well\u2010known dietary fiber with various beneficial functions, which the higher viscous GM is proposed to have the stronger potencies. Application of highly viscous GM to various food industries is limited for the sake of long elapsed time required to solubilize the GM. Thus, the exploration into any physiological function of low\u2010viscous GM remained undone for a long time. Male 4\u2010week\u2010old NC\/Nga mice, a model of atopic dermatitis (AD), were fed for 8 weeks on diets containing 5% each of a high\u2010viscous GM powder, ordinary konjac or highly purified GM, and a low\u2010viscous GM powder, pulverized GM or re\u2010granulated fine GM. Striking suppression to the aggravation of dermatitis and the increases in scratching behaviors and IgE levels was significantly observed only in mice fed on the pulverized GM diet, but not in mice fed on the other GM diets or a control diet. We concluded that the low\u2010viscous GM possesses a novel immunoregulatory function and the intensity of the function depends upon the particle size rather than the viscosity.<\/jats:p>","DOI":"10.1002\/biof.552210133","type":"journal-article","created":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T01:30:31Z","timestamp":1229650231000},"page":"163-166","source":"Crossref","is-referenced-by-count":10,"title":["The ability of konjac\u2010glucomannan to suppress spontaneously occurring dermatitis in NC\/Nga mice depends upon the particle size"],"prefix":"10.1002","volume":"21","author":[{"given":"Nobukazu","family":"Onishi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Kawamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsunehiro","family":"Aki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiko","family":"Shigeta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisao","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197107)28:1<3::AID-CNCR2820280104>3.0.CO;2-N"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(82)90104-5"},{"key":"e_1_2_1_4_2","first-page":"S190","article-title":"Effect of konjac fibre (glucomannan) on glucose and lipid","volume":"49","author":"Doi K.","year":"1995","journal-title":"Eur. J. Clin. Nutr."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/9.3.461"}],"container-title":["BioFactors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbiof.552210133","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.552210133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T13:40:24Z","timestamp":1693489224000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/biof.552210133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":4,"journal-issue":{"issue":"1-4","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1002\/biof.552210133"],"URL":"https:\/\/doi.org\/10.1002\/biof.552210133","archive":["Portico"],"relation":{},"ISSN":["0951-6433","1872-8081"],"issn-type":[{"value":"0951-6433","type":"print"},{"value":"1872-8081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}