{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:22:09Z","timestamp":1791832929366,"version":"4.3.4"},"reference-count":9,"publisher":"Wiley","issue":"1-4","license":[{"start":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T00:00:00Z","timestamp":1229385600000},"content-version":"vor","delay-in-days":1811,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioFactors"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diallyl sulfide (DAS), diallyl disulfide (DADS) and diallyl trisulfide (DATS) are principal constituents of garlic oil. We studied the effect of these sulfides on the phase II drug\u2010metabolizing enzymes, and on the rat model of acute liver injury induced by carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>). A highly purified form of each sulfide (more than 99% purity) was administered i.p. to rats at a concentration of 10 or 100 \u03bcmol\/kg body weight for 14 consecutive days. DATS (10 \u03bcmol\/kg) and DADS at a 10\u2010fold higher dose (100 \u03bcmol\/kg) significantly increased the activities of glutathione S\u2010transferase (GST) and quinone reductase (QR); whereas DAS did not. In the CCl<jats:sub>4<\/jats:sub>\u2010induced acute liver injury model of rats, DATS (10 \u03bcmol\/kg) significantly suppressed the increase in plasma lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) activities. In conclusion, hepatic phase II enzymes were induced strongly by the trisulfide and weakly by the disulfide, but not by DAS. DATS significantly reduced the liver injury caused by CCl<jats:sub>4<\/jats:sub>. DATS may be one of the important factors in garlic oil that protects our body against the injury caused by radical molecules.<\/jats:p>","DOI":"10.1002\/biof.552210135","type":"journal-article","created":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T01:30:28Z","timestamp":1229650228000},"page":"171-174","source":"Crossref","is-referenced-by-count":25,"title":["Chemoprotective effect of diallyl trisulfide from garlic against carbon tetrachloride\u2010induced acute liver injury of rats"],"prefix":"10.1002","volume":"21","author":[{"given":"Tomomi","family":"Fukao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hosono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Misawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiichiro","family":"Seki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyohiko","family":"Ariga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520130138"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.3.1027S"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-960119"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC402_18"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/00498259409043230"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb1961.49.359"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520120102"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051632198"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(00)00098-3"}],"container-title":["BioFactors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbiof.552210135","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/biof.552210135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T13:40:28Z","timestamp":1693489228000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1002\/biof.552210135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":9,"journal-issue":{"issue":"1-4","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1002\/biof.552210135"],"URL":"https:\/\/doi.org\/10.1002\/biof.552210135","archive":["Portico"],"relation":{},"ISSN":["0951-6433","1872-8081"],"issn-type":[{"value":"0951-6433","type":"print"},{"value":"1872-8081","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}