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KLF10 has been shown to be rapidly induced by TGF\u03b21, 2, 3, E<jats:sub>2<\/jats:sub>, epidermal growth factor, and bone morphogenetic protein\u20102. TGF\u03b2 inducible early gene\u20101 activates the TGF\u03b2\u2010Smad signaling pathway via repression of Smad 7 expression and activation of Smad 2 expression and activity. Overall, KLF10 has been implicated in cell differentiation, as a target gene for a variety of signaling pathways, and in serving as a potential marker for human diseases such as breast cancer, cardiac hypertrophy, and osteoporosis. Like other KLF members, KLF10 is expressed in specific cell types in numerous tissues and is known to be involved in repressing cell proliferation and inflammation as well as inducing apoptosis similar to that of TGF\u03b2. KLF10 binds to Sp\u20101\u2010GC rich DNA sequences and can activate or repress the transcription of a number of genes. Overall, KLF10 has been shown to play a major role in the TGF\u03b2 inhibition of cell proliferation and inflammation and induction of apoptosis, and its overexpression in human osteoblasts and pancreatic carcinoma cells mimics the actions of TGF\u03b2.<\/jats:p>","DOI":"10.1002\/biof.67","type":"journal-article","created":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T14:01:39Z","timestamp":1263909699000},"page":"8-18","source":"Crossref","is-referenced-by-count":108,"title":["Functional role of KLF10 in multiple disease processes"],"prefix":"10.1002","volume":"36","author":[{"given":"Malayannan","family":"Subramaniam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Hawse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalini M.","family":"Rajamannan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James N.","family":"Ingle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Spelsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,19]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/23.23.4907"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.9.11.1610"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1998.5388"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007177623283"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900878"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.41.29500"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000135200"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0330175"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19981001)71:1<96::AID-JCB10>3.0.CO;2-G"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2007-0253"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119418"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.40.25929"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19980201)68:2<226::AID-JCB9>3.0.CO;2-X"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(02)00331-5"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310634200"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412627200"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1377"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00211-9"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-22-08657.1997"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10856"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:BREA.0000032926.74216.7d"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204812200"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312638200"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2005.12.013"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.07.008"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.278.4.G513"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300620"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2003.09.045"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.15.5041-5049.2001"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.10.2451"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0534783100"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.3.5830"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205681"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10299"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.02.004"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)01051-0"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2005.01.013"},{"key":"e_1_2_10_39_2","first-page":"319","article-title":"Identification of genes responsive to apoptosis in HL\u201060 cells","volume":"25","author":"Jin W.","year":"2004","journal-title":"Acta Pharmacol. 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